Pemetrexed (pemetrexed disodium) NDC 72603-425

NDC codes

FDA NDC Directory

Product NDC (as listed)72603-425Labeler and product segments. Claims need a package NDC.

Product NDC at billing width72603-0425Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
72603-425-01	72603042501	1 VIAL, SINGLE-DOSE in 1 CARTON (72603-425-01) / 50 mL in 1 VIAL, SINGLE-DOSEMarketed from Oct 1, 2024

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Pemetrexed
Generic name (nonproprietary): pemetrexed disodium
Active ingredients: Pemetrexed disodium hemipentahydrate — 500 mg/50mL
Dosage form: Injection, Powder, Lyophilized, For solution
Route: Intravenous
Labeler: NorthStar RxLLC
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 208696
Marketing start: Oct 1, 2024
Listing expires: Dec 31, 2026
Other FDA classes: Folic Acid Metabolism Inhibitors (Mechanism)
Identifiers: Product ID 72603-425_c754c764-7f07-480c-b130-c5ce64cf0b80SPL ID c754c764-7f07-480c-b130-c5ce64cf0b80SPL set ID 64f4a9ed-26ff-4bc7-bef1-4faa98b35563RxCUI 1728072, 1728077UNII F4GSH45R4CUPC 0372603425017, 0372603325010
Pharmacologic class: Folate Analog Metabolic Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

Administration

Drug administration (CPT 96360–96549)

When a clinician administers the drug, the administration is reported separately. Codes in this range cover hydration, therapeutic injections and infusions, and chemotherapy or other complex drug administration. The right code depends on route, duration and drug type, and self-administered drugs are not billed this way.

How CPT relates to drug billing

NDC on a medical claim

N472603042501 followed by a unit qualifier and the quantity

Package 72603-0425-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Sep 10, 2024.

Indications (excerpt from the label)

Pemetrexed for Injection is a folate analog metabolic inhibitor indicated: in combination with pembrolizumab and platinum chemotherapy, for the initial treatment of patients with metastatic non-squamous non-small cell lung cancer (NSCLC), with no EGFR or ALK genomic tumor aberrations. ( 1.1 ) in combination with cisplatin for the initial treatment of patients with locally advanced or metastatic, non-squamous NSCLC. ( 1.1 ) as a single agent for the maintenance treatment of patients with locally advanced or metastatic, non-squamous NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy. ( 1.1 ) as a single agent for the treatment of patients with re…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under ANDA 208696

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 208696
Product	Strength	Form · route	Labeler	Product NDC
Pemetrexedpemetrexed disodium	Pemetrexed disodium hemipentahydrate 100 mg/10mL	Injection, Powder, Lyophilized, For solutionIntravenous	NorthStar RxLLC	72603-325
Pemetrexedpemetrexed disodium	Pemetrexed disodium hemipentahydrate 500 mg/50mL	Injection, Powder, Lyophilized, For solutionIntravenous	Meitheal Pharmaceuticals Inc.	71288-167
Pemetrexedpemetrexed disodium	Pemetrexed disodium hemipentahydrate 100 mg/10mL	Injection, Powder, Lyophilized, For solutionIntravenous	Meitheal Pharmaceuticals Inc.	71288-166
Pemetrexedpemetrexed disodium	Pemetrexed disodium hemipentahydrate 100 mg/10mL	Injection, Powder, Lyophilized, For solutionIntravenous	Meitheal Pharmaceuticals Inc.	71288-166
Pemetrexedpemetrexed disodium	Pemetrexed disodium hemipentahydrate 500 mg/50mL	Injection, Powder, Lyophilized, For solutionIntravenous	Meitheal Pharmaceuticals Inc.	71288-167