NDC codes

FDA NDC Directory
Product NDC (as listed)59651-574Labeler and product segments. Claims need a package NDC.
Product NDC at billing width59651-0574Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
59651-574-0859651057408120 TABLET in 1 BOTTLE (59651-574-08)Marketed from Jun 9, 2025
59651-574-2459651057424240 TABLET in 1 BOTTLE (59651-574-24)Marketed from Jun 9, 2025
59651-574-305965105743030 TABLET in 1 BOTTLE (59651-574-30)Marketed from Jun 9, 2025

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Sapropterin Dihydrochloride
Generic name (nonproprietary)
sapropterin dihydrochloride
Active ingredients
Sapropterin dihydrochloride — 100 mg/1
Dosage form
Tablet
Route
Oral
Product type
Prescription drug
Marketing category
ANDA — Abbreviated New Drug Application (generic)Application ANDA 216797
Marketing start
Listing expires
Other FDA classes
Breast Cancer Resistance Protein Inhibitors (Mechanism)P-Glycoprotein Inhibitors (Mechanism)Phenylalanine Hydroxylase Activators (Mechanism)
Identifiers
Product ID 59651-574_11ee25bc-f501-4f9d-b63d-63b2eee0147eSPL ID 11ee25bc-f501-4f9d-b63d-63b2eee0147eSPL set ID 11ee25bc-f501-4f9d-b63d-63b2eee0147eRxCUI 1486687UNII RG277LF5B3UPC 0359651574300
Pharmacologic class
Phenylalanine Hydroxylase Activator

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N459651057408 followed by a unit qualifier and the quantity

Package 59651-0574-08. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective .

Indications (excerpt from the label)

Sapropterin dihydrochloride tablets are indicated to reduce blood phenylalanine (Phe) levels in adult and pediatric patients one month of age and older with hyperphenylalaninemia (HPA) due to tetrahydrobiopterin- (BH4-) responsive Phenylketonuria (PKU). Sapropterin dihydrochloride tablets are to be used in conjunction with a Phe-restricted diet. Sapropterin dihydrochloride tablets are a phenylalanine hydroxylase activator indicated to reduce blood phenylalanine (Phe) levels in adult and pediatric patients one month of age and older with hyperphenylalaninemia (HPA) due to tetrahydrobiopterin- (BH4-) responsive Phenylketonuria (PKU). Sapropterin dihydrochloride tablets are to be used in conjun…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

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