NDC codes

FDA NDC Directory
Product NDC (as listed)52817-850Labeler and product segments. Claims need a package NDC.
Product NDC at billing width52817-0850Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
52817-850-01528170850011 POWDER, FOR SOLUTION in 1 POUCH (52817-850-01)Marketed from Jan 30, 2026
52817-850-305281708503030 POWDER, FOR SOLUTION in 1 CARTON (52817-850-30)Marketed from Jan 30, 2026

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Sapropterin Dihydrochloride
Generic name (nonproprietary)
sapropterin dihydrochloride
Active ingredients
Sapropterin dihydrochloride — 100 mg/1
Dosage form
Powder, For solution
Route
Oral
Product type
Prescription drug
Marketing category
ANDA — Abbreviated New Drug Application (generic)Application ANDA 216432
Marketing start
Listing expires
Other FDA classes
Breast Cancer Resistance Protein Inhibitors (Mechanism)P-Glycoprotein Inhibitors (Mechanism)Phenylalanine Hydroxylase Activators (Mechanism)
Identifiers
Product ID 52817-850_4b1fe6f7-f641-ec9a-e063-6394a90a4e04SPL ID 4b1fe6f7-f641-ec9a-e063-6394a90a4e04SPL set ID 39f1d020-4359-401b-88a8-ed25eaa40b45RxCUI 1111018, 1653217UNII RG277LF5B3
Pharmacologic class
Phenylalanine Hydroxylase Activator

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N452817085001 followed by a unit qualifier and the quantity

Package 52817-0850-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective .

Indications (excerpt from the label)

Sapropterin dihydrochloride powder for oral solution is indicated to reduce blood phenylalanine (Phe) levels in adult and pediatric patients one month of age and older with hyperphenylalaninemia (HPA) due to tetrahydrobiopterin- (BH4-) responsive Phenylketonuria (PKU). Sapropterin dihydrochloride powder for oral solution is to be used in conjunction with a Phe- restricted diet. Sapropterin dihydrochloride powder for oral solution is a phenylalanine hydroxylase activator indicated to reduce blood phenylalanine (Phe) levels in adult and pediatric patients one month of age and older with hyperphenylalaninemia (HPA) due to tetrahydrobiopterin- (BH4-) responsive Phenylketonuria (PKU). Sapropterin…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

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