What is NDC 21130-593?

21130-593 is the product NDC for Naproxen Sodium, Naproxen sodium 220 mg/1 tablet, film coated, listed with the FDA by Safeway. It has 1 package NDC, shown above in 10- and 11-digit form.

Safeway, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Naproxen Sodium?

143 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Naproxen Sodium NDC 21130-593 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)21130-593Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21130-0593Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21130-593-79	21130059379	400 TABLET, FILM COATED in 1 BOTTLE (21130-593-79)Marketed from Aug 13, 2025

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Naproxen Sodium
Generic name (nonproprietary): naproxen sodium
Active ingredients: Naproxen sodium — 220 mg/1
Dosage form: Tablet, Film coated
Route: Oral
Labeler: SafewayNDC labeler code 21130
Product type: Over-the-counter drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 074661
Marketing start: Aug 13, 2025
Listing expires: Dec 31, 2026
Other FDA classes: Non-Steroidal (Chemical structure)Cyclooxygenase Inhibitors (Mechanism)
Identifiers: Product ID 21130-593_e8a8e1bb-2989-4193-b172-4d2a6c33d9b7SPL ID e8a8e1bb-2989-4193-b172-4d2a6c33d9b7SPL set ID 396f4e60-3dde-433f-b4b5-25f351c96d57RxCUI 849574UNII 9TN87S3A3C
Pharmacologic class: Nonsteroidal Anti-inflammatory Drug

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421130059379 followed by a unit qualifier and the quantity

Package 21130-0593-79. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Aug 19, 2025.

Indications (excerpt from the label)

Uses • temporarily relieves minor aches and pains due to: • minor pain of arthritis • muscular aches • backache • menstrual cramps • headache • toothache • the common cold • temporarily reduces fever

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 21130-593

What is NDC 21130-593?: 21130-593 is the product NDC for Naproxen Sodium, Naproxen sodium 220 mg/1 tablet, film coated, listed with the FDA by Safeway. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Naproxen Sodium.
What is the active ingredient?: Naproxen sodium.
Who is the labeler?: Safeway, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Naproxen Sodium?: 143 other product NDCs are listed under this name. See all Naproxen Sodium NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Naproxen Sodium NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
naproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Amazon.com Services LLC	72288-988	72288-0988-75
Naproxen Sodium	Naproxen sodium 550 mg/1	TabletOral	Advanced Rx of Tennessee, LLC	80425-0574	80425-0574-0180425-0574-0280425-0574-03
Naproxen Sodium	Naproxen sodium 220 mg/1	Tablet, CoatedOral	HYVEE INC	42507-245	42507-0245-0142507-0245-14
Naproxen Sodium	Naproxen sodium 220 mg/1	Tablet, CoatedOral	HYVEE INC	42507-844	42507-0844-0142507-0844-14
Naproxen Sodium	Naproxen sodium 220 mg/1	Capsule, Liquid filledOral	TARGET Corporation	11673-651	11673-0651-78
Naproxen Sodium	Naproxen sodium 550 mg/1	TabletOral	Advanced Rx of Tennessee, LLC	80425-0531	80425-0531-0180425-0531-0280425-0531-03
Naproxen Sodium	Naproxen sodium 550 mg/1	TabletOral	Advanced Rx of Tennessee, LLC	80425-0532	80425-0532-0180425-0532-0280425-0532-03
Naproxen Sodium	Naproxen sodium 220 mg/1	Tablet, CoatedOral	CHAIN DRUG MARKETING ASSOCIATION, INC.	83324-108	83324-0108-0183324-0108-2483324-0108-50
Naproxen Sodium	Naproxen sodium 220 mg/1	Tablet, CoatedOral	CHAIN DRUG MARKETING ASSOCIATION, INC.	83324-109	83324-0109-0183324-0109-50
Naproxen Sodiumnaproxen sodium 220mg	Naproxen sodium 220 mg/1	TabletOral	CVS Pharmacy, Inc.	51316-608	51316-0608-90

All 144 Naproxen Sodium NDCs

Other NDCs under ANDA 074661

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 074661
Product	Strength	Form · route	Labeler	Product NDC
All Day Pain Reliefnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Walgreen Company	0363-0368
all day pain reliefnaproxen sodium	Naproxen sodium 200 mg/1	Tablet, Film coatedOral	Walgreen Company	0363-0938
All Day Reliefnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Publix Super Markets Inc	56062-368
all day reliefnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Publix Super Markets Inc	56062-490
Basic Care Naproxen Sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Amazon.com Services LLC	72288-331
basic care naproxen sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Amazon.com Services LLC	72288-368
Basic Care Naproxen Sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Amazon.com Services LLC	72288-489
Berkley and Jensen Naproxen Sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	BJWC	68391-368
betr headache pain reliefnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Live Betr LLC	80267-001
Care One Naproxen Sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	American Sales Company	41520-349
Care One Naproxen Sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	American Sales Company	41520-533
CareOne Naproxen Sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	American Sales Company	41520-507
DG Health Naproxen Sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Dolgencorp Inc	55910-481
DG Health Naproxen Sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Dolgencorp Inc	55910-490
dg health naproxen sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Dolgencorp Inc	55910-500
dg health naproxen sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Dolgencorp Inc	55910-729
equaline naproxen sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	United Natural Foods, Inc. dba UNFI	41163-511
equaline naproxen sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	United Natural Foods, Inc. dba UNFI	41163-707
exchange select naproxen sodiumnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Army & Air Force Exchange Service	55301-368
foster and thrive all day pain reliefnaproxen sodium	Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Strategic Sourcing Services LLC	70677-1137

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