NDC codes

FDA NDC Directory
Product NDC (as listed)83831-111Labeler and product segments. Claims need a package NDC.
Product NDC at billing width83831-0111Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
83831-111-01838310111011 VIAL in 1 CARTON (83831-111-01) / 4 mL in 1 VIALMarketed from Jan 1, 2025

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Pemetrexed Dipotassium
Generic name (nonproprietary)
pemetrexed dipotassium
Active ingredients
Pemetrexed — 100 mg/4mL
Dosage form
Injection, Powder, Lyophilized, For solution
Route
Intravenous
Product type
Prescription drug
Marketing category
NDA — New Drug ApplicationApplication NDA 210661
Marketing start
Listing expires
Other FDA classes
Folic Acid Metabolism Inhibitors (Mechanism)
Identifiers
Product ID 83831-111_0c1baa15-83bb-45a0-a3ab-855a4fee9129SPL ID 0c1baa15-83bb-45a0-a3ab-855a4fee9129SPL set ID adc9ce4c-926a-4ee8-bd0d-d06fc89c17fcRxCUI 1728072, 1728077UNII 04Q9AIZ7NOUPC 0383831111016, 0383831112013
Pharmacologic class
Folate Analog Metabolic Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

Administration

Drug administration (CPT 96360–96549)

When a clinician administers the drug, the administration is reported separately. Codes in this range cover hydration, therapeutic injections and infusions, and chemotherapy or other complex drug administration. The right code depends on route, duration and drug type, and self-administered drugs are not billed this way.

How CPT relates to drug billing

NDC on a medical claim

N483831011101 followed by a unit qualifier and the quantity

Package 83831-0111-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective .

Indications (excerpt from the label)

Pemetrexed for Injection is a folate analog metabolic inhibitor indicated: in combination with cisplatin for the initial treatment of patients with locally advanced or metastatic, non-squamous NSCLC. ( 1.1 ) as a single agent for the maintenance treatment of patients with locally advanced or metastatic, non-squamous NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy. ( 1.1 ) as a single agent for the treatment of patients with recurrent, metastatic non-squamous, NSCLC after prior chemotherapy. ( 1.1 ) Limitations of Use : Pemetrexed for Injection is not indicated for the treatment of patients with squamous cell, non-small cell lung cancer. ( 1.…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under NDA 210661

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 210661
ProductStrengthForm · routeLabelerProduct NDC
Pemetrexed DipotassiumPemetrexed 500 mg/20mLInjection, Powder, Lyophilized, For solutionIntravenousAvyxa Pharma, LLC83831-112
AxtlepemetrexedPemetrexed 500 mg/20mLInjection, Powder, Lyophilized, For solutionIntravenousAvyxa Pharma, LLC83831-132
AxtlepemetrexedPemetrexed 100 mg/4mLInjection, Powder, Lyophilized, For solutionIntravenousAvyxa Pharma, LLC83831-131

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