What is NDC 81777-105?

81777-105 is the product NDC for Xesso Strawberry Rear Comfort Glide 4% Lidocaine, Lidocaine hydrochloride 4.625 g/100mL gel, listed with the FDA by Premium Natural Cosmetics Inc. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Xesso Strawberry Rear Comfort Glide 4% Lidocaine (Lidocaine).

Premium Natural Cosmetics Inc, NDC labeler code 81777. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Xesso Strawberry Rear Comfort Glide 4% Lidocaine?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

NDC 81777-105

NDC codes

FDA NDC Directory

Product NDC (as listed)81777-105Labeler and product segments. Claims need a package NDC.

Product NDC at billing width81777-0105Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
81777-105-01	8177701050181777010501	245 mL in 1 BOTTLE, PLASTIC (81777-105-01)Marketed from Dec 13, 2022

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Xesso Strawberry Rear Comfort Glide 4% Lidocaine
Generic name (nonproprietary): lidocaine
Active ingredients: Lidocaine hydrochloride — 4.625 g/100mL
Dosage form: Gel
Route: Rectal
Labeler: Premium Natural Cosmetics IncNDC labeler code 81777
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 015
Marketing start: Dec 13, 2022
Listing expires: Dec 31, 2026
Other FDA classes: Amides (Chemical structure)Local Anesthesia (Physiologic effect)
Identifiers: Product ID 81777-105_4162e5d1-8387-b313-e063-6294a90afc0dSPL ID 4162e5d1-8387-b313-e063-6294a90afc0dSPL set ID efba09fc-6dd7-0f73-e053-2995a90a628aUNII V13007Z41A
Pharmacologic class: Amide Local Anesthetic; Antiarrhythmic

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

NDC on a medical claim

N481777010501 followed by a unit qualifier and the quantity

Package 81777-0105-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Oct 17, 2025.

Indications (excerpt from the label)

Use For temporary relief of pain, soreness, or burning in the perianal area.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 81777-105

What is NDC 81777-105?: 81777-105 is the product NDC for Xesso Strawberry Rear Comfort Glide 4% Lidocaine, Lidocaine hydrochloride 4.625 g/100mL gel, listed with the FDA by Premium Natural Cosmetics Inc. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Xesso Strawberry Rear Comfort Glide 4% Lidocaine (Lidocaine).
What is the active ingredient?: Lidocaine hydrochloride.
Who is the labeler?: Premium Natural Cosmetics Inc, NDC labeler code 81777. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Xesso Strawberry Rear Comfort Glide 4% Lidocaine?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under M 015

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 015
Product	Strength	Form · route	Labeler	Product NDC
Hempvana Maximum Strength Pain Relief Topical Anesthetic Platinumlidocaine 5%	Lidocaine 5 g/100g	CreamTopical	Telebrands Corp	73287-040
Nupharmisto NumbMD LIDOCAINE cream anorectal (hemorrhoidal)lidocaine cream anorectal	Lidocaine 4 g/80g	CreamTopical	EveryMarket Inc	85833-002
Lidonumblidocaine 5%	Lidocaine .05 g/g	CreamTopical	Rising Pharma Holdings, Inc.	57237-353
Exchange Select Hemorrhoidalcocoa butter, phenylephrine hcl	Cocoa butter 2211 mg/1; Phenylephrine hydrochloride 6.5 mg/1	SuppositoryRectal	Army & Air Force Exchange Service	55301-279
Preparation H Medicated Wipeswitch hazel	Witch hazel 5 g/1	ClothTopical	Haleon US Holdings LLC	0573-0557
Lidocaine anorectal creamlidocaine 5%	Lidocaine 5 g/100g	CreamTopical	EveryMarket Inc	85833-001
hemorrhoidalcocoa butter, phenylephrine hcl	Cocoa butter 2211 mg/1; Phenylephrine hydrochloride 6.5 mg/1	SuppositoryRectal	Kroger Company	30142-279
hemorrhoidalcocoa butter, phenylephrine hcl	Cocoa butter 2211 mg/1; Phenylephrine hydrochloride 6.5 mg/1	SuppositoryRectal	Meijer Distribution Inc	41250-279
hemorrhoidal maximum strength pain reliefglycerin, phenylephrine hcl, pramoxine hcl, white petrolatum	Glycerin 14.4 g/100g + 3 more ingredients	CreamTopical	Kroger Company	30142-944
Oxifylidocaine 5%	Lidocaine 50 mg/g	CreamTopical	Weeks & Leo Compnay, INC.	11383-331
hemorrhoidalglycerin, phenylephrine hcl, pramoxine hcl, white petrolatum	Glycerin 14.4 g/100g + 3 more ingredients	CreamTopical	Publix Super Markets Inc	56062-944
Black Label B Numblidocaine hydrochloride	Lidocaine hydrochloride 5 g/100mL	SprayTopical	SCALP TECH INC	82617-103
hemorrhoidalmineral oil, petrolatum, phenylephrine hcl	Mineral oil 14 g/100g + 2 more ingredients	OintmentRectal	Amazon.com Services LLC	72288-767
The Solutionlidocaine hydrochloride, epinephrine hydrochloride	Lidocaine hydrochloride 5 g/100mL; Epinephrine hydrochloride .01 g/100mL	SprayTopical	SCALP TECH INC	82617-101
Good Sense Hemorrhoidal Maximum Strength Pain Reliefglycerin, phenylephrine hcl, pramoxine hcl, white petrolatum	Glycerin 14.4 g/100g + 3 more ingredients	CreamTopical	L. Perrigo Company	0113-0944
The Solution 2.0lidocaine	Lidocaine hydrochloride 5 g/100mL	SprayTopical	SCALP TECH INC	82617-102
Equaline Hemorrhoidalcocoa butter, phenylephrine hcl	Cocoa butter 2211 mg/1; Phenylephrine hydrochloride 6.5 mg/1	SuppositoryRectal	United Natural Foods, Inc. dba UNFI	41163-279
Walgreens Moisture Barriermenthol, and zinc oxide	Menthol .44 g/100g; Zinc oxide 20.6 g/100g	CreamTopical	Walgreen Company	0363-3680
The Solu Tionlidocaine hydrochloride and epinephrine hydrochloride	Lidocaine hydrochloride 5 g/100mL; Epinephrine hydrochloride .01 g/100mL	Aerosol, FoamTopical	SCALP TECH INC	82617-110
Maximum Strength Hemorrhoidal Cream with Aloeglycerin, phenylephine hci, pramoxine hci, petrolatum	White petrolatum 15 g/100g + 3 more ingredients	CreamTopical	Chain Drug Marketing Association	83324-330

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Xesso Strawberry Rear Comfort Glide 4% Lidocaine (Lidocaine) NDC 81777-105