What is NDC 72189-686?

72189-686 is the product NDC for Loperamide HCl, Loperamide hydrochloride 2 mg/1 capsule, listed with the FDA by Direct_Rx. It has 1 package NDC, shown above in 10- and 11-digit form.

Direct_Rx, NDC labeler code 72189. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Loperamide HCl?

1 other product NDC are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Loperamide HCl NDC 72189-686 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)72189-686Labeler and product segments. Claims need a package NDC.

Product NDC at billing width72189-0686Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
72189-686-20	7218906862072189068620	20 CAPSULE in 1 BOTTLE (72189-686-20)Marketed from Aug 25, 2026

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Loperamide HCl
Generic name (nonproprietary): loperamide hcl
Active ingredients: Loperamide hydrochloride — 2 mg/1
Dosage form: Capsule
Route: Oral
Labeler: Direct_RxNDC labeler code 72189
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 218122
Marketing start: Aug 25, 2026
Listing expires: Dec 31, 2027
Other FDA classes: Opioid Agonists (Mechanism)
Identifiers: Product ID 72189-686_59e1c4cf-17cd-13c9-e063-6294a90af61cSPL ID 59e1c4cf-17cd-13c9-e063-6294a90af61cSPL set ID 59e1c4cf-17cc-13c9-e063-6294a90af61cRxCUI 978006UNII 77TI35393C
Pharmacologic class: Opioid Agonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N472189068620 followed by a unit qualifier and the quantity

Package 72189-0686-20. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Aug 25, 2026. This label includes a boxed warning.

Indications (excerpt from the label)

Loperamide hydrochloride capsules are indicated for the control and symptomatic relief of acute nonspecific diarrhea in patients 2 years of age and older and of chronic diarrhea in adults associated with inflammatory bowel disease. Loperamide hydrochloride capsules are also indicated for reducing the volume of discharge from ileostomies.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 72189-686

What is NDC 72189-686?: 72189-686 is the product NDC for Loperamide HCl, Loperamide hydrochloride 2 mg/1 capsule, listed with the FDA by Direct_Rx. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Loperamide HCl.
What is the active ingredient?: Loperamide hydrochloride.
Who is the labeler?: Direct_Rx, NDC labeler code 72189. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Loperamide HCl?: 1 other product NDC are listed under this name. See all Loperamide HCl NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Loperamide HCl NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Loperamide HCl	Loperamide hydrochloride 2 mg/1	TabletOral	L.N.K. International, Inc.	50844-735	50844-0735-0250844-0735-0850844-0735-19+4 more

Other NDCs under ANDA 218122

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 218122
Product	Strength	Form · route	Labeler	Product NDC
Loperamide Hydrochloride	Loperamide hydrochloride 2 mg/1	CapsuleOral	Major Pharmaceuticals	0904-7472
Loperamide Hydrochloride	Loperamide hydrochloride 2 mg/1	CapsuleOral	A-S Medication Solutions	50090-7398
Loperamide Hydrochloride	Loperamide hydrochloride 2 mg/1	CapsuleOral	Aurobindo Pharma Limited	59651-691
Loperamide Hydrochloride	Loperamide hydrochloride 2 mg/1	CapsuleOral	Coupler LLC	67046-1676
Loperamide Hydrochloride	Loperamide hydrochloride 2 mg/1	CapsuleOral	Redpharm Drug	67296-2172
Loperamide Hydrochloride	Loperamide hydrochloride 2 mg/1	CapsuleOral	NuCare Pharmaceuticals,Inc.	68071-3618
Loperamide Hydrochloride	Loperamide hydrochloride 2 mg/1	CapsuleOral	NuCare Pharmaceuticals,Inc.	68071-5331
Loperamide Hydrochloride	Loperamide hydrochloride 2 mg/1	CapsuleOral	REMEDYREPACK INC.	70518-4283
Loperamide Hydrochloride	Loperamide hydrochloride 2 mg/1	CapsuleOral	Bryant Ranch Prepack	71335-2571
Loperamide Hydrochloride	Loperamide hydrochloride 2 mg/1	CapsuleOral	NorthStar Rx LLC	72603-328