NDC codes

FDA NDC Directory
Product NDC (as listed)71335-2378Labeler and product segments. Claims need a package NDC.
Product NDC at billing width71335-2378Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
71335-2378-17133523780130 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2378-1)Marketed from Apr 16, 2024
71335-2378-27133523780260 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2378-2)Marketed from Jun 12, 2024
71335-2378-37133523780390 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2378-3)Marketed from Mar 27, 2024
71335-2378-471335237804120 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2378-4)Marketed from Jan 31, 2025
71335-2378-57133523780514 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2378-5)Marketed from Jan 31, 2025

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Bupropion Hydrochloride XLSuffix: XL
Generic name (nonproprietary)
bupropion hydrochloride
Active ingredients
Bupropion hydrochloride — 150 mg/1
Dosage form
Tablet, Extended release
Route
Oral
Product type
Prescription drug
Marketing category
ANDA — Abbreviated New Drug Application (generic)Application ANDA 210015
Marketing start
Listing expires
Other FDA classes
Dopamine Uptake Inhibitors (Mechanism)Increased Dopamine Activity (Physiologic effect)Increased Norepinephrine Activity (Physiologic effect)Norepinephrine Uptake Inhibitors (Mechanism)
Identifiers
Product ID 71335-2378_12d8178a-effc-4b53-b907-c909c80faab8SPL ID 12d8178a-effc-4b53-b907-c909c80faab8SPL set ID eb25adb1-9841-42ce-aa22-718fb0fba5ddRxCUI 993541UNII ZG7E5POY8O
Pharmacologic class
Aminoketone

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N471335237801 followed by a unit qualifier and the quantity

Package 71335-2378-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective . This label includes a boxed warning.

Indications (excerpt from the label)

Bupropion hydrochloride extended-release tablets (XL) are an aminoketone antidepressant, indicated for: • treatment of major depressive disorder (MDD) ( 1.1 ) • prevention of seasonal affective disorder (SAD) ( 1.2 ) 1.1 Major Depressive Disorder (MDD) Bupropion hydrochloride extended-release tablets (XL) are indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM). The efficacy of the immediate-release formulation of bupropion was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult patients with MDD. The efficacy of the sustained-release formulation of bupropion in the main…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under ANDA 210015

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 210015
ProductStrengthForm · routeLabelerProduct NDC
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 300 mg/1Tablet, Extended releaseOralA-S Medication Solutions50090-6961
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 300 mg/1Tablet, Extended releaseOralA-S Medication Solutions50090-6962
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 150 mg/1Tablet, Extended releaseOralNuCare Pharmacueticals, Inc.68071-3594
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 300 mg/1Tablet, Extended releaseOralEpic Pharma, LLC42806-416
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 150 mg/1Tablet, Extended releaseOralEpic Pharma, LLC42806-414
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 150 mg/1Tablet, Extended releaseOralProficient Rx LP71205-394
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 150 mg/1Tablet, Extended releaseOralPD-Rx Pharmaceuticals, Inc.72789-377
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 300 mg/1Tablet, Extended releaseOralREMEDYREPACK INC.70518-4014
Bupropion HCL ER (XL)Bupropion hydrochloride 300 mg/1Tablet, Extended releaseOralDirect_RX72189-539
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 150 mg/1Tablet, Extended releaseOralSlate Run Pharmaceuticals, LLC70436-010
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 300 mg/1Tablet, Extended releaseOralSlate Run Pharmaceuticals, LLC70436-011
Bupropion Hydrochloride XLbupropion hydrochlorideBupropion hydrochloride 150 mg/1Tablet, Extended releaseOralProficient Rx LP82804-080

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