What is NDC 71335-0226?

71335-0226 is the product NDC for Estradiol, Estradiol .5 mg/1 tablet, listed with the FDA by Bryant Ranch Prepack. It has 4 package NDCs, shown above in 10- and 11-digit form.

Bryant Ranch Prepack, NDC labeler code 71335. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Estradiol?

181 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Estradiol NDC 71335-0226 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)71335-0226Labeler and product segments. Claims need a package NDC.

Product NDC at billing width71335-0226Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package
71335-0226-1	71335022601	30 TABLET in 1 BOTTLE (71335-0226-1)Marketed from Jun 29, 2018
71335-0226-2	71335022602	100 TABLET in 1 BOTTLE (71335-0226-2)Marketed from Dec 27, 2021
71335-0226-3	71335022603	90 TABLET in 1 BOTTLE (71335-0226-3)Marketed from May 7, 2018
71335-0226-4	71335022604	60 TABLET in 1 BOTTLE (71335-0226-4)Marketed from Dec 27, 2021

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Estradiol
Generic name (nonproprietary): estradiol
Active ingredients: Estradiol — .5 mg/1
Dosage form: Tablet
Route: Oral
Labeler: Bryant Ranch PrepackNDC labeler code 71335
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 040275
Marketing start: Apr 10, 2017
Listing expires: Dec 31, 2026
Other FDA classes: Estradiol Congeners (Chemical structure)Estrogen Receptor Agonists (Mechanism)
Identifiers: Product ID 71335-0226_4593e1f2-65b0-4a0f-ac69-0f2be718c63eSPL ID 4593e1f2-65b0-4a0f-ac69-0f2be718c63eSPL set ID fad3813c-9495-416b-9789-623d5758b4e3RxCUI 197657UNII 4TI98Z838E
Pharmacologic class: Estrogen

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N471335022601 followed by a unit qualifier and the quantity

Package 71335-0226-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Mar 28, 2025. This label includes a boxed warning.

Indications (excerpt from the label)

INDICATIONS AND USAGE Estradiol tablets are indicated in the: 1. Treatment of moderate to severe vasomotor symptoms associated with the menopause. 2. Treatment of moderate to severe symptoms of vulvar and vaginal atrophy associated with the menopause. When prescribing solely for the treatment of symptoms of vulvar and vaginal atrophy, topical vaginal products should be considered. 3. Treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure. 4. Treatment of breast cancer (for palliation only) in appropriately selected women and men with metastatic disease. 5. Treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). 6. Prevention …

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 71335-0226

What is NDC 71335-0226?: 71335-0226 is the product NDC for Estradiol, Estradiol .5 mg/1 tablet, listed with the FDA by Bryant Ranch Prepack. It has 4 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Estradiol.
What is the active ingredient?: Estradiol.
Who is the labeler?: Bryant Ranch Prepack, NDC labeler code 71335. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Estradiol?: 181 other product NDCs are listed under this name. See all Estradiol NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Estradiol NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Estradiol	Estradiol .75 mg/1.25g	GelTransdermal	Encube Ethicals, Inc.	21922-015	21922-0015-40
Estradiol	Estradiol .75 mg/1.25g	GelTopical	Solaris Pharma Corporation	73473-308	73473-0308-50
Estradiol	Estradiol .5 mg/1	TabletOral	Direct_Rx	72189-655	72189-0655-60
Estradiol	Estradiol .5 mg/1	TabletOral	Coupler LLC	67046-1568	67046-1568-03
Estradiol	Estradiol 1 mg/1	TabletOral	American Health Packaging	60687-876	60687-0876-65
Estradiol	Estradiol 1 mg/1	TabletOral	Preferred Pharmaceuticals Inc.	68788-8860	68788-8860-0168788-8860-0368788-8860-06+1 more
Estradiol	Estradiol .75 mg/1.25g	Gel, MeteredTopical	ANI Pharmaceuticals, Inc.	70954-646	70954-0646-10
Estradiolestradiol transdermal	Estradiol 1.25 mg/1.25g	GelTopical	Amneal Pharmaceuticals NY LLC	69238-2448	69238-2448-03
Estradiolestradiol transdermal	Estradiol 1 mg/g	GelTopical	Amneal Pharmaceuticals NY LLC	69238-2449	69238-2449-03
Estradiolestradiol transdermal	Estradiol .75 mg/.75g	GelTopical	Amneal Pharmaceuticals NY LLC	69238-2450	69238-2450-03

All 182 Estradiol NDCs

Other NDCs under ANDA 040275

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 040275
Product	Strength	Form · route	Labeler	Product NDC
Estradiol	Estradiol .5 mg/1	TabletOral	PURACAP LABORATORIES, LLC	24658-702
Estradiol	Estradiol 1 mg/1	TabletOral	PURACAP LABORATORIES, LLC	24658-703
Estradiol	Estradiol 2 mg/1	TabletOral	PURACAP LABORATORIES, LLC	24658-704
Estradiol	Estradiol .5 mg/1	TabletOral	EPIC PHARMA, LLC	42806-087
Estradiol	Estradiol 1 mg/1	TabletOral	EPIC PHARMA, LLC	42806-088
Estradiol	Estradiol 2 mg/1	TabletOral	EPIC PHARMA, LLC	42806-089
Estradiol	Estradiol .5 mg/1	TabletOral	A-S Medication Solutions	50090-5494
Estradiol	Estradiol 1 mg/1	TabletOral	A-S Medication Solutions	50090-6359
Estradiol	Estradiol 2 mg/1	TabletOral	A-S Medication Solutions	50090-6363
Estradiol	Estradiol 1 mg/1	TabletOral	A-S Medication Solutions	50090-7452
Estradiol	Estradiol .5 mg/1	TabletOral	Northwind Health Company, LLC	51655-860
Estradiol	Estradiol 2 mg/1	TabletOral	Bryant Ranch Prepack	63629-4788
Estradiol	Estradiol 1 mg/1	TabletOral	NuCare Pharmaceuticals, Inc.	68071-3394
Estradiol	Estradiol 2 mg/1	TabletOral	NuCare Pharmaceuticals,Inc.	68071-4485
Estradiol	Estradiol 1 mg/1	TabletOral	Preferred Pharmaceuticals Inc.	68788-7102
Estradiol	Estradiol 2 mg/1	TabletOral	REMEDYREPACK INC.	70518-2829
Estradiol	Estradiol 1 mg/1	TabletOral	REMEDYREPACK INC.	70518-3818
Estradiol	Estradiol 1 mg/1	TabletOral	Bryant Ranch Prepack	71335-0797
Estradiol	Estradiol 1 mg/1	TabletOral	Direct_Rx	72189-502
Estradiol	Estradiol 2 mg/1	TabletOral	Direct_Rx	72189-508

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