NDC codes

FDA NDC Directory
Product NDC (as listed)70121-2716Labeler and product segments. Claims need a package NDC.
Product NDC at billing width70121-2716Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
70121-2716-2701212716025 SYRINGE in 1 BOX (70121-2716-2) / 10 mL in 1 SYRINGEMarketed from Mar 3, 2025

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Methylene blue
Generic name (nonproprietary)
methylene blue
Active ingredients
Methylene blue — 5 mg/mL
Dosage form
Injection, Solution
Route
Intravenous
Labeler
Amneal Pharmaceuticals LLCNDC labeler code 70121
Product type
Prescription drug
Marketing category
ANDA — Abbreviated New Drug Application (generic)Application ANDA 216955
Marketing start
Listing expires
Other FDA classes
Oxidation-Reduction Activity (Mechanism)
Identifiers
Product ID 70121-2716_3d0c528f-71c3-4517-93f8-901307496e01SPL ID 3d0c528f-71c3-4517-93f8-901307496e01SPL set ID 67da2a69-8166-46c7-921c-d6ec47bfeac8RxCUI 1788984, 2731634UNII T42P99266KUPC 0370121271529
Pharmacologic class
Oxidation-Reduction Agent

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

Administration

Drug administration (CPT 96360–96549)

When a clinician administers the drug, the administration is reported separately. Codes in this range cover hydration, therapeutic injections and infusions, and chemotherapy or other complex drug administration. The right code depends on route, duration and drug type, and self-administered drugs are not billed this way.

How CPT relates to drug billing

NDC on a medical claim

N470121271602 followed by a unit qualifier and the quantity

Package 70121-2716-02. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective . This label includes a boxed warning.

Indications (excerpt from the label)

Methylene blue injection, USP is indicated for the treatment of pediatric and adult patients with acquired methemoglobinemia. Methylene blue injection is an oxidation-reduction agent indicated for the treatment of pediatric and adult patients with acquired methemoglobinemia.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 70121-2716

What is NDC 70121-2716?
70121-2716 is the product NDC for Methylene blue, Methylene blue 5 mg/mL injection, solution, listed with the FDA by Amneal Pharmaceuticals LLC. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?
Methylene blue.
What is the active ingredient?
Methylene blue.
Who is the labeler?
Amneal Pharmaceuticals LLC, NDC labeler code 70121. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Methylene blue?
18 other product NDCs are listed under this name. See all Methylene blue NDCs.
Is there a related HCPCS / J-code?
Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Methylene blue NDCs
ProductStrengthForm · routeLabelerProduct NDCPackage NDCs (11-digit)
Methylene blueMethylene blue 10 mg/mLInjectionIntravenousZydus Lifesciences Limited70771-196370771-1963-0170771-1963-05
Methylene blueMethylene blue 10 mg/mLInjectionIntravenousZydus Pharmaceuticals USA Inc.70710-208370710-2083-0170710-2083-05
Methylene blueMethylene blue 50 mg/10mLInjection, SolutionIntravenousSteriscience Specialties Private Limited82449-00382449-0003-06
Methylene BlueMethylene blue 50 mg/10mLInjectionIntravenousChengdu Shuode Pharmaceutical Co., Ltd82432-10482432-0104-02
Methylene BlueMethylene blue 50 mg/10mLInjectionIntravenousGLENMARK PHARMACEUTICALS INC., USA68462-69868462-0698-15
Methylene BlueMethylene blue 50 mg/10mLInjectionIntravenousXIROMED, LLC70700-32870700-0328-24
Methylene blueMethylene blue 5 mg/mLInjection, SolutionIntravenousHikma Pharmaceuticals USA Inc.0143-909400143-9094-05
Methylene blueMethylene blue 5 mg/mLInjection, SolutionIntravenousAmneal Pharmaceuticals LLC70121-271570121-2715-02
Methylene blueMethylene blue 50 mg/10mLInjection, SolutionIntravenousSteriscience Specialties Private Limited82449-00282449-0002-06
Methylene BlueMethylene blue 5 mg/mLInjection, SolutionIntravenousNexus Pharmaceuticals, LLC14789-11914789-0119-05

All 19 Methylene blue NDCs

Other NDCs under ANDA 216955

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 216955
ProductStrengthForm · routeLabelerProduct NDC
Methylene blueMethylene blue 50 mg/10mLInjection, SolutionIntravenousSteriscience Specialties Private Limited82449-002
Methylene blueMethylene blue 50 mg/10mLInjection, SolutionIntravenousSteriscience Specialties Private Limited82449-003
Methylene blueMethylene blue 5 mg/mLInjection, SolutionIntravenousAmneal Pharmaceuticals LLC70121-2715

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