Lisinopril and Hydrochlorothiazide NDC 68645-557

NDC codes

FDA NDC Directory

Product NDC (as listed)68645-557Labeler and product segments. Claims need a package NDC.

Product NDC at billing width68645-0557Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
68645-557-54	68645055754	30 TABLET in 1 BOTTLE (68645-557-54)Marketed from Apr 10, 2006

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Lisinopril and Hydrochlorothiazide
Generic name (nonproprietary): lisinopril and hydrochlorothiazide
Active ingredients: Hydrochlorothiazide — 12.5 mg/1Lisinopril — 20 mg/1
Dosage form: Tablet
Route: Oral
Labeler: Legacy Pharmaceutical Packaging, LLC
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 077912
Marketing start: Apr 10, 2006
Listing expires: Dec 31, 2027
Other FDA classes: Angiotensin-converting Enzyme Inhibitors (Mechanism)Increased Diuresis (Physiologic effect)Thiazides (Chemical structure)
Identifiers: Product ID 68645-557_4c4ae743-258c-e380-e063-6394a90af48aSPL ID 4c4ae743-258c-e380-e063-6394a90af48aSPL set ID 6d729ec5-7311-4534-9999-9d6fa4f3ba2fRxCUI 197885, 197886, 197887UNII 0J48LPH2TH, E7199S1YWRUPC 0368645556543, 0368645557540, 0368645558547
Pharmacologic class: Angiotensin Converting Enzyme Inhibitor; Thiazide Diuretic

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N468645055754 followed by a unit qualifier and the quantity

Package 68645-0557-54. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Mar 5, 2026. This label includes a boxed warning.

Indications (excerpt from the label)

INDICATIONS AND USAGE Lisinopril and hydrochlorothiazide tablets USP are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including lisinopril and hydrochlorothiazide. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will …

Excerpt only. Read the full label for complete information.

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