Divigel (estradiol) NDC 68025-066

NDC codes

FDA NDC Directory

Product NDC (as listed)68025-066Labeler and product segments. Claims need a package NDC.

Product NDC at billing width68025-0066Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
68025-066-07	68025006607	7 PACKET in 1 CARTON (68025-066-07) / .5 g in 1 PACKETMarketed from Oct 27, 2014
68025-066-30	68025006630	30 PACKET in 1 CARTON (68025-066-30) / .5 g in 1 PACKETMarketed from Oct 27, 2014

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Divigel
Generic name (nonproprietary): estradiol
Active ingredients: Estradiol — .5 mg/.5g
Dosage form: Gel
Route: Topical
Labeler: Vertical Pharmaceuticals, LLC
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 022038
Marketing start: Oct 27, 2014
Listing expires: Dec 31, 2027
Other FDA classes: Estradiol Congeners (Chemical structure)Estrogen Receptor Agonists (Mechanism)
Identifiers: Product ID 68025-066_077120b4-1172-49bc-b197-363f410589abSPL ID 077120b4-1172-49bc-b197-363f410589abSPL set ID 59e610dc-883e-4f07-9ec6-a5841b0bf9fbRxCUI 2619677, 2619678, 2619679, 2619680, 2619681, 2619682, 2619683, 2619684, 2619685, 2619686UNII 4TI98Z838E
Pharmacologic class: Estrogen

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Topical products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N468025006607 followed by a unit qualifier and the quantity

Package 68025-0066-07. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Feb 27, 2026. This label includes a boxed warning.

Indications (excerpt from the label)

Divigel is an estrogen indicated for the treatment of moderate to severe vasomotor symptoms due to menopause ( 1.1 ). 1.1 Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under NDA 022038

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 022038
Product	Strength	Form · route	Labeler	Product NDC
Estradiol	Estradiol .25 mg/.25g	GelTopical	Trigen Laboratories, LLC	13811-090
Estradiol	Estradiol 1 mg/g	GelTopical	Trigen Laboratories, LLC	13811-093
Estradiol	Estradiol .5 mg/.5g	GelTopical	Trigen Laboratories, LLC	13811-091
Estradiol	Estradiol .75 mg/.75g	GelTopical	Trigen Laboratories, LLC	13811-092
Estradiol	Estradiol 1.25 mg/1.25g	GelTopical	Trigen Laboratories, LLC	13811-094
Divigelestradiol	Estradiol .25 mg/.25g	GelTopical	Vertical Pharmaceuticals, LLC	68025-065
Divigelestradiol	Estradiol 1 mg/g	GelTopical	Vertical Pharmaceuticals, LLC	68025-067
Divigelestradiol	Estradiol 1.25 mg/1.25g	GelTopical	Vertical Pharmaceuticals, LLC	68025-086
Divigelestradiol	Estradiol .75 mg/.75g	GelTopical	Vertical Pharmaceuticals, LLC	68025-083