Avonex (interferon beta-1a) NDC 59627-002

NDC codes

FDA NDC Directory

Product NDC (as listed)59627-002Labeler and product segments. Claims need a package NDC.

Product NDC at billing width59627-0002Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
59627-002-06	59627000206	1 TRAY in 1 CARTON (59627-002-06) / 1 SYRINGE in 1 TRAY (59627-002-07) / .5 mL in 1 SYRINGEMarketed from May 23, 2003

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Avonex
Generic name (nonproprietary): interferon beta-1a
Active ingredients: Interferon beta-1a — 30 ug/.5mL
Dosage form: Injection, Solution
Route: Intramuscular
Labeler: Biogen Inc.
Product type: Prescription drug
Marketing category: BLA — Biologics License ApplicationApplication BLA 103628
Marketing start: May 23, 2003
Listing expires: Dec 31, 2026
Other FDA classes: Interferon-beta (Chemical structure)
Identifiers: Product ID 59627-002_8c84155d-4436-404a-bb05-aee683889f0bSPL ID 8c84155d-4436-404a-bb05-aee683889f0bSPL set ID d70a39cc-de15-4c12-a1ec-8063b69ea0e1RxCUI 727813, 727816, 797544, 1650899, 1650901UNII XRO4566Q4RUPC 0359627002066
Pharmacologic class: Interferon beta

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

Administration

Drug administration (CPT 96360–96549)

When a clinician administers the drug, the administration is reported separately. Codes in this range cover hydration, therapeutic injections and infusions, and chemotherapy or other complex drug administration. The right code depends on route, duration and drug type, and self-administered drugs are not billed this way.

How CPT relates to drug billing

NDC on a medical claim

N459627000206 followed by a unit qualifier and the quantity

Package 59627-0002-06. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Nov 19, 2025.

Indications (excerpt from the label)

AVONEX is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. AVONEX is for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. ( 1 )

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under BLA 103628

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under BLA 103628
Product	Strength	Form · route	Labeler	Product NDC
Avonex Peninterferon beta-1a	Interferon beta-1a 30 ug/.5mL	Injection, SolutionIntramuscular	Biogen Inc.	59627-003
Avonexinterferon beta-1a	—	KitIntramuscular	Biogen Inc.	59627-222
Avonexinterferon beta-1a	—	KitIntramuscular	Biogen Inc.	59627-333