Over-the-counter drug · OTC MONOGRAPH DRUG
Diphenhydramine Hydrochloride NDC 55154-1589
Diphenhydramine hydrochloride 25 mg/1 · Tablet · Oral · Cardinal Health 107, LLC
NDC codes
FDA NDC DirectoryProduct NDC (as listed)55154-1589Labeler and product segments. Claims need a package NDC.
Product NDC at billing width55154-1589Add the package segment from the table below.
| Package NDC | 11-digit (billing) | Package | Copy |
|---|---|---|---|
| 55154-1589-0 | 55154158900 | 1 BLISTER PACK in 1 BAG (55154-1589-0) / 10 TABLET in 1 BLISTER PACKMarketed from Aug 7, 2026 |
How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules
Product information
- Brand name (proprietary)
- Diphenhydramine Hydrochloride
- Generic name (nonproprietary)
- diphenhydramine hydrochloride
- Active ingredients
- Diphenhydramine hydrochloride — 25 mg/1
- Dosage form
- Tablet
- Route
- Oral
- Labeler
- Cardinal Health 107, LLCNDC labeler code 55154
- Product type
- Over-the-counter drug
- Marketing category
- OTC monograph drugApplication M 012
- Marketing start
- Listing expires
- Other FDA classes
- Histamine H1 Receptor Antagonists (Mechanism)
- Identifiers
- Product ID 55154-1589_887cabe5-46d0-4f4e-8f5a-2cfdbc157b58SPL ID 887cabe5-46d0-4f4e-8f5a-2cfdbc157b58SPL set ID 887cabe5-46d0-4f4e-8f5a-2cfdbc157b58RxCUI 1049630UNII TC2D6JAD40UPC 0055154158909
- Pharmacologic class
- Histamine-1 Receptor Antagonist
Billing references
What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.
- HCPCS codeNo match
No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.
- NDC on a medical claim
N455154158900followed by a unit qualifier and the quantityPackage 55154-1589-00. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier
Product label
Current FDA label (SPL), effective .
Indications (excerpt from the label)
Uses ▪ temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: ▪ runny nose ▪ sneezing ▪ itchy, watery eyes ▪ itching of nose ▪ temporarily relieves these symptoms due to the common cold: ▪ runny nose ▪ sneezing
Excerpt only. Read the full label for complete information.
About NDC 55154-1589
- What is NDC 55154-1589?
- 55154-1589 is the product NDC for Diphenhydramine Hydrochloride, Diphenhydramine hydrochloride 25 mg/1 tablet, listed with the FDA by Cardinal Health 107, LLC. It has 1 package NDC, shown above in 10- and 11-digit form.
- What drug is associated with this NDC?
- Diphenhydramine Hydrochloride.
- What is the active ingredient?
- Diphenhydramine hydrochloride.
- Who is the labeler?
- Cardinal Health 107, LLC, NDC labeler code 55154. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
- What other NDCs exist for Diphenhydramine Hydrochloride?
- 81 other product NDCs are listed under this name. See all Diphenhydramine Hydrochloride NDCs.
- Is there a related HCPCS / J-code?
- Not in Med-Code's curated HCPCS directory. See Billing references above.
Related NDCs: other Diphenhydramine Hydrochloride products
Other finished products listed under the same name: strengths, forms and labelers.
| Product | Strength | Form · route | Labeler | Product NDC | Package NDCs (11-digit) |
|---|---|---|---|---|---|
| Diphenhydramine Hydrochloride | Diphenhydramine hydrochloride 25 mg/1 | Tablet, Film coatedOral | Health Pharma USA LLC | 71679-308 | 71679-0308-00 |
| Diphenhydramine hydrochloride | Diphenhydramine hydrochloride 12.5 mg/5mL | SolutionOral | Camber Pharmaceuticals, Inc. | 31722-600 | 31722-0600-1131722-0600-31 |
| Diphenhydramine hydrochloride | Diphenhydramine hydrochloride 25 mg/10mL | SolutionOral | Camber Pharmaceuticals, Inc. | 31722-601 | 31722-0601-31 |
| Diphenhydramine Hydrochloride | Diphenhydramine hydrochloride 50 mg/mL | InjectionIntramuscular, Intravenous | REMEDYREPACK INC. | 70518-4536 | 70518-4536-00 |
| Diphenhydramine Hydrochloride | Diphenhydramine hydrochloride 50 mg/mL | InjectionIntramuscular, Intravenous | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | 23155-263 | 23155-0263-31 |
| Diphenhydramine Hydrochloride | Diphenhydramine hydrochloride 50 mg/mL | InjectionIntramuscular, Intravenous | Micro Labs Limited | 42571-511 | 42571-0511-56 |
| Diphenhydramine hydrochloride | Diphenhydramine hydrochloride 50 mg/mL | InjectionIntramuscular, Intravenous | REMEDYREPACK INC. | 70518-4455 | 70518-4455-00 |
| Diphenhydramine Hydrochloride | Diphenhydramine hydrochloride 50 mg/1 | Capsule, Liquid filledOral | Prodose, Inc. | 68210-5057 | 68210-5057-01 |
| Diphenhydramine Hydrochloride | Diphenhydramine hydrochloride 50 mg/mL | InjectionIntramuscular, Intravenous | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | 23155-264 | 23155-0264-41 |
| Diphenhydramine Hydrochloride | Diphenhydramine hydrochloride 50 mg/mL | InjectionIntramuscular, Intravenous | Medical Purchasing Solutions, LLC | 71872-7373 | 71872-7373-01 |
Other NDCs under M 012
Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.
| Product | Strength | Form · route | Labeler | Product NDC |
|---|---|---|---|---|
| Quality Choice Menthol Cough Dropsmenthol cough drops | Menthol 5.4 mg/1 | LozengeOral | Chain Drug Marketing Association, Inc. | 83324-265 |
| 12 Hour Original Nasal Decongestantnasal spray | Oxymetazoline hydrochloride 50 mg/100mL | LiquidNasal | Sheffield Pharmaceuticals LLC | 11527-140 |
| nasal decongestantoxymetazoline hydrochloride | Oxymetazoline hydrochloride .05 g/100mL | SprayNasal | Safeway | 21130-420 |
| Cold and Flu Daytime Nighttimeacetaminophen, dextromethorphan hbr, doxylamine succinate, phenylephrine hcl | — | Kit | CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED | 51316-123 |
| Mucus Relief All in One Maximum Strengthacetaminophen, dextromethorphan hbr, guaifenesin, phenylephrine hcl | Dextromethorphan hydrobromide 20 mg/20mL + 3 more ingredients | LiquidOral | Dolgencorp, Inc. (DOLLAR GENERAL & REXALL) | 55910-886 |
| Cold and Flu Reliefacetaminophen dextromethorphan hbr phenylephrine hcl | Acetaminophen 325 mg/15mL + 2 more ingredients | LiquidOral | Family Dollar (FAMILY WELLNESS) | 55319-646 |
| Childrens Plus Cough and Runny Noseacetaminophen, chlorpheniramine maleate, dextromethorphan hydrobromide | Acetaminophen 160 mg/5mL + 2 more ingredients | SuspensionOral | Dolgencorp, Inc. (DOLLAR GENERAL & REXALL) | 55910-297 |
| Giltuss Cough and Colddextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride | Dextromethorphan hydrobromide 15 mg/5mL + 2 more ingredients | SolutionOral | Gil Pharmaceutical Corp | 58552-130 |
| Best Choice Maximum Strengthoxymetazoline hydrochloride | Oxymetazoline hydrochloride .05 g/100mL | SprayNasal | BEST CHOICE (VALU MERCHANDISERS COMPANY) | 63941-718 |
| Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Nightaspirin, dextromethorphan hydrobromide, phenylephrine bitartrate | — | KitOral | Bayer HealthCare LLC. | 0280-0086 |
| McKesson Phenylephrine HClphenylephrine hcl | Phenylephrine hydrochloride 5 mg/1 | Tablet, Film coatedOral | McKesson Medical-Surgical | 68599-1631 |
| Topcare Chest Congestion and Sinus Congestion Relief PEguaifenesin/phenylephrine | Guaifenesin 400 mg/1; Phenylephrine hydrochloride 10 mg/1 | TabletOral | TOPCO ASSOCIATES LLC | 36800-989 |
| Chest Rubcamphor, eucalyptus oil, menthol | Menthol 26 mg/g + 2 more ingredients | JellyTopical | Hy-Vee, Inc. | 42507-248 |
| XL-3 Day Timeacetaminophen, dextromethorphan hbr, phenylephrine hcl | Dextromethorphan hydrobromide 10 mg/15mL + 2 more ingredients | LiquidOral | Rnv LLC | 84379-441 |
| 7 Select Maximum Strengthdextromethorphan hbr, guaifenesin | Dextromethorphan hydrobromide 20 mg/20mL; Guaifenesin 400 mg/20mL | SolutionOral | 7-ELEVEN | 10202-740 |
| ASP Nighttime Maxacetaminophen, dextromethorphan hydrobromide, doxylamine succinate, phenylephrine hydrochloride | Acetaminophen 325 mg/1 + 3 more ingredients | Capsule, Liquid filledOral | Humanwell PuraCap Pharmaceutical (Wuhan), Ltd. | 53345-053 |
| Alka-Seltzer Plus Cold and Fluchlorpheniramine maleate, acetaminophen, phenylephrine hydrochloride, dextromethorphan hydrobromide tablet | Acetaminophen 250 mg/1 + 3 more ingredients | Tablet, EffervescentOral | Lil' Drug Store Products, Inc. | 66715-9831 |
| Cold and Flu Relief Daytimeacetaminophen, dextromethorphan hydrobromide, phenylephrine hydrochloride | Acetaminophen 325 mg/1 + 2 more ingredients | Capsule, Liquid filledOral | H E B | 37808-864 |
| Cold Reliefacetaminophen, dextromethorphan hbr, phenylephrine hcl | Acetaminophen 325 mg/1 + 2 more ingredients | Tablet, Film coatedOral | United Natural Foods, Inc. dba UNFI | 41163-907 |
| CareOne Severe Congestion Nasaloxymetazoline hydrochloride | Oxymetazoline hydrochloride .05 g/100mL | SprayNasal | American Sales Company | 41520-108 |
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