Akovaz (ephedrine sulfate) NDC 51754-4200

NDC codes

FDA NDC Directory

Product NDC (as listed)51754-4200Labeler and product segments. Claims need a package NDC.

Product NDC at billing width51754-4200Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
51754-4200-4	51754420004	25 VIAL, SINGLE-DOSE in 1 CARTON (51754-4200-4) / 1 mL in 1 VIAL, SINGLE-DOSEMarketed from Apr 15, 2021

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Akovaz
Generic name (nonproprietary): ephedrine sulfate
Active ingredients: Ephedrine sulfate — 50 mg/mL
Dosage form: Injection
Route: Intravenous
Labeler: Exela Pharma Sciences, LLC
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 208289
Marketing start: Apr 15, 2021
Listing expires: Dec 31, 2026
Other FDA classes: Adrenergic alpha-Agonists (Mechanism)Adrenergic beta-Agonists (Mechanism)Increased Norepinephrine Activity (Physiologic effect)
Identifiers: Product ID 51754-4200_5a627a89-7997-4af5-a1d0-2cedbe1bc868SPL ID 5a627a89-7997-4af5-a1d0-2cedbe1bc868SPL set ID e92f3eda-33eb-4b34-9e8b-db8d32a5dbd9RxCUI 1116294, 1796730, 2586841, 2586845UNII U6X61U5ZEG
Pharmacologic class: Norepinephrine Releasing Agent; alpha-Adrenergic Agonist; beta-Adrenergic Agonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

Administration

Drug administration (CPT 96360–96549)

When a clinician administers the drug, the administration is reported separately. Codes in this range cover hydration, therapeutic injections and infusions, and chemotherapy or other complex drug administration. The right code depends on route, duration and drug type, and self-administered drugs are not billed this way.

How CPT relates to drug billing

NDC on a medical claim

N451754420004 followed by a unit qualifier and the quantity

Package 51754-4200-04. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Nov 27, 2020.

Indications (excerpt from the label)

AKOVAZ (ephedrine sulfate injection) is indicated for the treatment of clinically important hypotension occurring in the setting of anesthesia. AKOVAZ injection is an alpha- and beta-adrenergic agonist and a norepinephrine-releasing agent that is indicated for the treatment of clinically important hypotension occurring in the setting of anesthesia. ( 1 )

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under NDA 208289

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 208289
Product	Strength	Form · route	Labeler	Product NDC
Akovazephedrine sulfate	Ephedrine sulfate 5 mg/mL	InjectionIntravenous	Exela Pharma Sciences, LLC	51754-4250