What is NDC 51316-681?

51316-681 is the product NDC for Daytime Severe Cold And Flu, Acetaminophen 325 mg/15mL + 3 more ingredients solution, listed with the FDA by CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Daytime Severe Cold And Flu (Acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride).

What is the active ingredient?

Acetaminophen, Dextromethorphan hydrobromide, Guaifenesin, Phenylephrine hydrochloride.

CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED, NDC labeler code 51316. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Daytime Severe Cold And Flu?

13 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Daytime Severe Cold And Flu NDC 51316-681

NDC codes

FDA NDC Directory

Product NDC (as listed)51316-681Labeler and product segments. Claims need a package NDC.

Product NDC at billing width51316-0681Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
51316-681-40	5131606814051316068140	355 mL in 1 BOTTLE (51316-681-40)Marketed from Jun 3, 2026

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Daytime Severe Cold And Flu
Generic name (nonproprietary): acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride
Active ingredients: Acetaminophen — 325 mg/15mLDextromethorphan hydrobromide — 10 mg/15mLGuaifenesin — 200 mg/15mLPhenylephrine hydrochloride — 5 mg/15mL
Dosage form: Solution
Route: Oral
Labeler: CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATEDNDC labeler code 51316
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 012
Marketing start: Jun 3, 2026
Listing expires: Dec 31, 2027
Other FDA classes: Adrenergic alpha1-Agonists (Mechanism)Decreased Respiratory Secretion Viscosity (Physiologic effect)Increased Respiratory Secretions (Physiologic effect)Sigma-1 Receptor Agonists (Mechanism)Uncompetitive NMDA Receptor Antagonists (Mechanism)
Identifiers: Product ID 51316-681_29e2cfb2-065c-4621-8514-3f4ab07c4368SPL ID 29e2cfb2-065c-4621-8514-3f4ab07c4368SPL set ID 493caecb-e687-49ea-b7a1-2a5b9376896dRxCUI 1369842UNII 362O9ITL9D, 9D2RTI9KYH, 495W7451VQ, 04JA59TNSJ
Pharmacologic class: Expectorant; Sigma-1 Agonist; Uncompetitive N-methyl-D-aspartate Receptor Antagonist; alpha-1 Adrenergic Agonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N451316068140 followed by a unit qualifier and the quantity

Package 51316-0681-40. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jun 8, 2026.

Indications (excerpt from the label)

Uses temporarily relieves common cold/flu symptoms: • sinus congestion and pressure • nasal congestion • minor aches and pains • headache • sore throat • fever • cough due to minor throat and bronchial irritation • reduces swelling of nasal passages • promotes nasal and/or sinus drainage • temporarily restores freer breathing through the nose • helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 51316-681

What is NDC 51316-681?: 51316-681 is the product NDC for Daytime Severe Cold And Flu, Acetaminophen 325 mg/15mL + 3 more ingredients solution, listed with the FDA by CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Daytime Severe Cold And Flu (Acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride).
What is the active ingredient?: Acetaminophen, Dextromethorphan hydrobromide, Guaifenesin, Phenylephrine hydrochloride.
Who is the labeler?: CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED, NDC labeler code 51316. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Daytime Severe Cold And Flu?: 13 other product NDCs are listed under this name. See all Daytime Severe Cold And Flu NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Daytime Severe Cold And Flu NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Daytime Severe Cold And Fluacetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride	Acetaminophen 325 mg/15mL + 3 more ingredients	SolutionOral	Amazon.com Services LLC	72288-655	72288-0655-40
daytime severe cold and fluacetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride	Acetaminophen 325 mg/15mL + 3 more ingredients	SolutionOral	Amazon.com Services LLC	72288-557	72288-0557-3472288-0557-40
daytime severe cold and fluacetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride	Acetaminophen 325 mg/1 + 3 more ingredients	Tablet, Film coatedOral	CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED	51316-731	51316-0731-62
Daytime Severe Cold and Fluacetaminophen,dextromethorphan hbr, guaifenesin, phenylephrine hcl	Phenylephrine hydrochloride 5 mg/15mL + 3 more ingredients	LiquidOral	Grocery Outlet, Inc.	85828-774	85828-0774-01
Daytime Severe Cold And Fluacetaminophen, dextromethorphan hbr, guaifenesin, phenylephrine hcl	Dextromethorphan hydrobromide 10 mg/1 + 3 more ingredients	CapsuleOral	CVS HEALTH CORP	51316-525	51316-0525-24
Daytime Severe Cold and Fluacetaminophen, dextromethorphan hbr	Dextromethorphan hydrobromide 20 mg/20mL; Acetaminophen 650 mg/20mL	SuspensionOral	Genexa Inc.	69676-0093	69676-0093-09
Daytime Severe Cold and Fluacetaminophen, dextromethorphan hbr, guaifenesin, phenylephrine hcl	Phenylephrine hydrochloride 5 mg/15mL + 3 more ingredients	LiquidOral	Kroger	41226-774	41226-0774-01
daytime severe cold and fluacetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride	Acetaminophen 325 mg/15mL + 3 more ingredients	SolutionOral	Walgreen Company	0363-5001	00363-5001-40
Daytime Severe Cold And Fluacetaminophen, phenylephrine hcl, dextromethorphan hbr, guaifenesin	Phenylephrine hydrochloride 5 mg/1 + 3 more ingredients	Capsule, Liquid filledOral	KROGER COMPANY	41226-625	41226-0625-24
daytime severe cold and fluacetaminophen, dextromethorphan hbr, guaifenesin, phenylephrine hcl	Acetaminophen 325 mg/15mL + 3 more ingredients	SolutionOral	H E B	37808-603	37808-0603-40

All 14 Daytime Severe Cold And Flu NDCs

Other NDCs under M 012

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 012
Product	Strength	Form · route	Labeler	Product NDC
Allergy Reliefdiphenhydramine hydrochloride	Diphenhydramine hydrochloride 25 mg/1	Tablet, Film coatedOral	WALGREENS	0363-0100
CVS Health No Dripnasal mist	Oxymetazoline hydrochloride .05 g/100mL	SprayNasal	CVS PHARMACY,INC.	69842-815
Vicks NyQuil VapoCOOL Severe COLD and FLU plus CONGESTIONacetaminophen, phenylephrine hydrochloride, doxylamine succinate, and dextromethorphan hydrobromide	Acetaminophen 325 mg/1 + 3 more ingredients	Tablet, CoatedOral	The Procter & Gamble Manufacturing Company	69423-986
Cold and Flu Nighttimeacetaminophen, dextromethorphan hbr, doxylamine succinate	Acetaminophen 650 mg/30mL + 2 more ingredients	SolutionOral	Lidl US LLC	71141-180
basic care tussin dm maxdextromethorphan hbr, guaifenesin	Dextromethorphan hydrobromide 20 mg/20mL; Guaifenesin 400 mg/20mL	SolutionOral	Amazon.com Services LLC	72288-293
Menthol Cough Drops Honey Vanilla Flavormenthol	Menthol 2.5 mg/1	LozengeOral	Xiamen Kang Zhongyuan Biotechnology Co., Ltd.	83698-013
equate daytime nighttime cold and fluacetaminophen, dextromethorphan hydrobromide, doxylamine succinate, guaifenesen, phenylephrine hydrochloride	—	Kit	Sixarp, LLC	59368-459
Nasal Decongestant Maximum Strengthpseudoephedrine hcl	Pseudoephedrine hydrochloride 30 mg/1	Tablet, Film coatedOral	Better Living Brands, LLC	21130-112
Medicated Chest Rubcamphor, menthol, eucalyptus oil	Camphor (Synthetic) 4.8 g/100g + 2 more ingredients	CreamTopical	Jell Pharmaceuticals Pvt Ltd.	30400-701
equaline nighttime cold and flu reliefacetaminophen, dextromethorphan hbr, doxylamine succinate	Acetaminophen 650 mg/30mL + 2 more ingredients	SolutionOral	United Natural Foods, Inc. dba UNFI	41163-459
NiteTime Cold and Fluacetaminophen, dextromethorphan hydrobromide, doxylamine succinate	Acetaminophen 650 mg/30mL + 2 more ingredients	LiquidOral	EQUATE (Wal-Mart Stores, Inc.) (see also WAL-MART INC)	49035-044
Childrens Dye Free Allergydiphenhydramine hydrochloride	Diphenhydramine hydrochloride 12.5 mg/5mL	LiquidOral	P & L Development, LLC	49580-0293
Discount Drug Mart Original Nasaloxymetazoline hydrochloride	Oxymetazoline hydrochloride .05 g/100mL	SprayNasal	DISCOUNT DRUG MART	53943-715
Cold, Flu and Sore Throatacetaminophen, dextromethorphan hbr, guaifenesin, phenylephrine hcl	Acetaminophen 650 mg/20mL + 3 more ingredients	SolutionOral	Family Dollar Services Inc	55319-705
DG Health Cold and Flu Severeacetaminophen, dextromethorphan hydrobromide, doxylamine succinate, phenylephrine hydrochloride	Acetaminophen 325 mg/15mL + 3 more ingredients	SolutionOral	Dolgencorp Inc	55910-928
Robitussin Severe Multi-Symptom Cough Cold Fluacetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride	Acetaminophen 650 mg/20mL + 3 more ingredients	LiquidOral	Haleon US Holdings LLC	0031-8751
Afrin No Drip Pump Mist Bundle Packoxymetazoline hydrochloride	—	KitNasal	Bayer HealthCare LLC.	11523-0147
Cold Medicine XL3acetaminophen chlorpheniramine maleate phenylepherine hydrochloride	Acetaminophen 325 mg/1 + 2 more ingredients	TabletOral	Selder, S.A. de C.V.	63654-605
Nasal Spray, 1oz, 24/7 Life by 7-Elevenoxymetazoline hcl nasal solution 0.05%	Oxymetazoline hydrochloride .05 g/100mL	SprayNasal	Lil' Drug Store Products, Inc.	66715-5526
Vicks childrens Cough Congestionphenylephrine hcl, dextromethorphan hbr, guaifenesin	Dextromethorphan hydrobromide 10 mg/15mL + 2 more ingredients	LiquidOral	The Procter & Gamble Manufacturing Company	69423-982

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