What is NDC 51316-662?

51316-662 is the product NDC for Cough and Sore Throat, Acetaminophen 650 mg/20mL; Dextromethorphan hydrobromide 20 mg/20mL liquid, listed with the FDA by CVS. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Cough and Sore Throat (Acetaminophen, Dextromethorphan Hydrobromide liquid).

What is the active ingredient?

Acetaminophen, Dextromethorphan hydrobromide.

CVS, NDC labeler code 51316. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Cough and Sore Throat?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Cough and Sore Throat NDC 51316-662 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)51316-662Labeler and product segments. Claims need a package NDC.

Product NDC at billing width51316-0662Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
51316-662-03	51316066203	180 mL in 1 BOTTLE (51316-662-03)Marketed from May 23, 2025

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Cough and Sore Throat
Generic name (nonproprietary): acetaminophen, dextromethorphan hydrobromide liquid
Active ingredients: Acetaminophen — 650 mg/20mLDextromethorphan hydrobromide — 20 mg/20mL
Dosage form: Liquid
Route: Oral
Labeler: CVSNDC labeler code 51316
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 012
Marketing start: May 2, 2025
Listing expires: Dec 31, 2026
Other FDA classes: Sigma-1 Receptor Agonists (Mechanism)Uncompetitive NMDA Receptor Antagonists (Mechanism)
Identifiers: Product ID 51316-662_3161682c-7349-d0ce-e063-6294a90ad18cSPL ID 3161682c-7349-d0ce-e063-6294a90ad18cSPL set ID 2d13564a-e8d1-c357-e063-6394a90ad90eRxCUI 1919076UNII 362O9ITL9D, 9D2RTI9KYH
Pharmacologic class: Sigma-1 Agonist; Uncompetitive N-methyl-D-aspartate Receptor Antagonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N451316066203 followed by a unit qualifier and the quantity

Package 51316-0662-03. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective May 2, 2025.

Indications (excerpt from the label)

Uses temporarily relieves: cough due to minor throat and bronchial irritation as may occur with the common cold or inhaled irritants the intensity of coughing the impulse to cough to help you get to sleep minor aches and pains sore throat headache temporarily reduces fever

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 51316-662

What is NDC 51316-662?: 51316-662 is the product NDC for Cough and Sore Throat, Acetaminophen 650 mg/20mL; Dextromethorphan hydrobromide 20 mg/20mL liquid, listed with the FDA by CVS. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Cough and Sore Throat (Acetaminophen, Dextromethorphan Hydrobromide liquid).
What is the active ingredient?: Acetaminophen, Dextromethorphan hydrobromide.
Who is the labeler?: CVS, NDC labeler code 51316. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Cough and Sore Throat?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under M 012

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 012
Product	Strength	Form · route	Labeler	Product NDC
topcare tussin cf maxacetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride	Acetaminophen 650 mg/20mL + 3 more ingredients	SolutionOral	Topco Associates LLC	76162-000
SEVERE CONGESTION and COUGH MAXdextromethorphan hbr, guaifenesin, phenylephrine hcl	Dextromethorphan hydrobromide 20 mg/20mL + 2 more ingredients	LiquidOral	AptaPharma Inc.	76281-517
Nighttime Cold And Flu Reliefacetaminophen, dextromethorphan hydrobromide, and doxylamine succinate	Dextromethorphan hydrobromide 15 mg/1 + 2 more ingredients	Capsule, Liquid filledOral	Advanced Rx LLC	80513-304
Quality Choice Mucus Reliefguaifenesin	Guaifenesin 400 mg/1	TabletOral	Chain Drug Marketing Association	83324-194
Pseudoephedrine Hydrochloride	Pseudoephedrine hydrochloride 60 mg/1	TabletOral	Major Pharmaceuticals	0904-6728
Nighttime Cold and Flu Liquidacetaminophen, dextromethorphan hydrobromide, doxylamine succinate	Acetaminophen 650 mg/30mL + 2 more ingredients	LiquidOral	TARGET CORPORATION	11673-287
Allergy Reliefdiphenhydramine hcl	Diphenhydramine hydrochloride 25 mg/1	TabletOral	TARGET CORPORATION	11673-494
Mucus Reliefguaifenesin	Guaifenesin 400 mg/1	TabletOral	KROGER COMPANY	41226-272
sinus pressure and pain peacetaminophen and phenylephrine hydrochloride	Acetaminophen 325 mg/1; Phenylephrine hydrochloride 5 mg/1	Tablet, CoatedOral	GOODSENSE	50804-220
Mucinex Sinus-Max Severe Congestion Reliefacetaminophen, guaifenesin, and phenylephrine hydrochloride	Acetaminophen 325 mg/1 + 2 more ingredients	Tablet, CoatedOral	Reckitt Benckiser LLC	63824-201
Oxymetazoline Hydrochloride	Oxymetazoline hydrochloride .05 g/100mL	SprayNasal	CHAIN DRUG MARKETING ASSOCIATION INC.	63868-676
Childrens Wal Tap Elixer Cold and Allergybrompheniramine maleate, phenylephrine hcl	Brompheniramine maleate 2 mg/10mL; Phenylephrine hydrochloride 5 mg/10mL	LiquidOral	Walgreens	0363-0312
Vicks NyQuil Kids BERRY COLD and COUGH plus RUNNY NOSEchlorpheniramine maleate, dextromethorphan hbr	Chlorpheniramine maleate 2 mg/15mL; Dextromethorphan hydrobromide 15 mg/15mL	LiquidOral	The Procter & Gamble Manufacturing Company	69423-779
Night-Time Cold and Flu Reliefacetaminophen, doxylamine succinate, dextromethorphan hbr	Acetaminophen 325 mg/1 + 2 more ingredients	Capsule, Liquid filledOral	HealthLife of USA	69517-161
Tylenol Sinus Severeacetaminophen	Acetaminophen 325 mg/1 + 2 more ingredients	Tablet, CoatedOral	R J General Corporation	70264-026
Tussin Expectorantguaifenesin	Guaifenesin 100 mg/5mL	LiquidOral	AptaPharma, Inc.	76281-507
ValuMeds Allergy Relief Antihistamine Diphenhydramine HCldiphenhydramine hydrochloride	Diphenhydramine hydrochloride 25 mg/1	TabletOral	Cabinet Health P.B.C.	82725-1101
Equate Severe Menthol Throat Dropmenthol	Menthol 20 mg/1	LozengeOral	Walmart	79903-254
Nighttime Cold And Flu Relief Softgels Multi-Symptomacetaminophen, dextromethorphan hbr, doxylamine succinate	Dextromethorphan hydrobromide 15 mg/1 + 2 more ingredients	Capsule, Gelatin coatedOral	Advanced Rx LLC	80513-302
Vicks NyQuil-D COLD and SINUS plus SEVERE CONGESTIONacetaminophen, pseudoephedrine hcl, doxylamine succinate, dextromethorphan hbr	Doxylamine succinate 6.25 mg/1 + 3 more ingredients	Capsule, Liquid filledOral	The Procter & Gamble Manufacturing Company	84126-364

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