NDC codes

FDA NDC Directory
Product NDC (as listed)50458-580Labeler and product segments. Claims need a package NDC.
Product NDC at billing width50458-0580Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
50458-580-07504580580077 TABLET, FILM COATED in 1 BOTTLE (50458-580-07)Marketed from Nov 1, 2017 · Sample package
50458-580-105045805801010 BLISTER PACK in 1 CARTON (50458-580-10) / 10 TABLET, FILM COATED in 1 BLISTER PACK (50458-580-01)Marketed from Jul 1, 2011
50458-580-305045805803030 TABLET, FILM COATED in 1 BOTTLE (50458-580-30)Marketed from Jul 1, 2011
50458-580-905045805809090 TABLET, FILM COATED in 1 BOTTLE (50458-580-90)Marketed from Nov 1, 2017

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Xarelto
Generic name (nonproprietary)
rivaroxaban
Active ingredients
Rivaroxaban — 10 mg/1
Dosage form
Tablet, Film coated
Route
Oral
Product type
Prescription drug
Marketing category
NDA — New Drug ApplicationApplication NDA 022406
Marketing start
Listing expires
Other FDA classes
Factor Xa Inhibitors (Mechanism)
Identifiers
Product ID 50458-580_5294926b-7812-41da-a0e8-56f492198450SPL ID 5294926b-7812-41da-a0e8-56f492198450SPL set ID 10db92f9-2300-4a80-836b-673e1ae91610RxCUI 1114198, 1114202, 1232082, 1232084, 1232086, 1232088, 1549682, 1549683, 2059015, 2059017, 2588062, 2588066UNII 9NDF7JZ4M3UPC 0350458575019, 0350458579307, 0350458580303, 0350458578300, 0350458577600
Pharmacologic class
Factor Xa Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N450458058007 followed by a unit qualifier and the quantity

Package 50458-0580-07. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective . This label includes a boxed warning.

Indications (excerpt from the label)

XARELTO is a factor Xa inhibitor indicated: to reduce risk of stroke and systemic embolism in nonvalvular atrial fibrillation ( 1.1 ) for treatment of deep vein thrombosis (DVT) ( 1.2 ) for treatment of pulmonary embolism (PE) ( 1.3 ) for reduction in the risk of recurrence of DVT or PE ( 1.4 ) for the prophylaxis of DVT, which may lead to PE in patients undergoing knee or hip replacement surgery ( 1.5 ) for prophylaxis of venous thromboembolism (VTE) in acutely ill medical patients ( 1.6 ) to reduce the risk of major cardiovascular events in patients with coronary artery disease (CAD) ( 1.7 ) to reduce the risk of major thrombotic vascular events in patients with peripheral artery disease (…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under NDA 022406

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 022406
ProductStrengthForm · routeLabelerProduct NDC
XareltorivaroxabanRivaroxaban 10 mg/1Tablet, Film coatedOralA-S Medication Solutions50090-4469
XareltorivaroxabanRivaroxaban 20 mg/1Tablet, Film coatedOralA-S Medication Solutions50090-4468
XareltorivaroxabanRivaroxaban 10 mg/1Tablet, Film coatedOralA-S Medication Solutions50090-3625
XareltorivaroxabanRivaroxaban 20 mg/1Tablet, Film coatedOralA-S Medication Solutions50090-3639
XareltorivaroxabanRivaroxaban 20 mg/1Tablet, Film coatedOralCardinal Health 107, LLC55154-1423
XareltorivaroxabanRivaroxaban 15 mg/1Tablet, Film coatedOralCardinal Health 107, LLC55154-1424
XareltorivaroxabanRivaroxaban 2.5 mg/1Tablet, Film coatedOralJanssen Pharmaceuticals, Inc.50458-577
XareltorivaroxabanRivaroxaban 20 mg/1Tablet, Film coatedOralJanssen Pharmaceuticals, Inc.50458-579
XareltorivaroxabanRivaroxaban 15 mg/1Tablet, Film coatedOralJanssen Pharmaceuticals, Inc.50458-578
Xareltorivaroxaban—KitJanssen Pharmaceuticals, Inc.50458-584
XareltorivaroxabanRivaroxaban 10 mg/1Tablet, Film coatedOralAphena Pharma Solutions - Tennessee, LLC71610-690

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