What is NDC 50419-403?

50419-403 is the product NDC for Safyral kit, listed with the FDA by Bayer HealthCare Pharmaceuticals Inc.. It has 4 package NDCs, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Safyral (Drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium).

Bayer HealthCare Pharmaceuticals Inc., NDC labeler code 50419. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Safyral?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Safyral NDC 50419-403 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)50419-403Labeler and product segments. Claims need a package NDC.

Product NDC at billing width50419-0403Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package
50419-403-00	50419040300	90 BLISTER PACK in 1 PACKAGE (50419-403-00) / 1 KIT in 1 BLISTER PACKMarketed from Feb 13, 2012
50419-403-03	50419040303	3 BLISTER PACK in 1 PACKAGE (50419-403-03) / 1 KIT in 1 BLISTER PACK (50419-403-01)Marketed from Feb 13, 2012
50419-403-70	50419040370	90 BLISTER PACK in 1 PACKAGE (50419-403-70) / 1 KIT in 1 BLISTER PACKMarketed from Feb 13, 2012
50419-403-75	50419040375	12 PACKAGE in 1 CARTON (50419-403-75) / 5 BLISTER PACK in 1 PACKAGE / 1 KIT in 1 BLISTER PACK (50419-403-71)Marketed from Feb 13, 2012

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Safyral
Generic name (nonproprietary): drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium
Dosage form: Kit
Labeler: Bayer HealthCare Pharmaceuticals Inc.NDC labeler code 50419
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 022574
Marketing start: Feb 13, 2012
Listing expires: Dec 31, 2027
Identifiers: Product ID 50419-403_e2c77609-66d5-4e76-8f2b-060c9e30b5e9SPL ID e2c77609-66d5-4e76-8f2b-060c9e30b5e9SPL set ID 97563516-306a-4e17-9690-edbda49ecd83RxCUI 1013628, 1050492, 1050493, 1050494

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

NDC on a medical claim

N450419040300 followed by a unit qualifier and the quantity

Package 50419-0403-00. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Mar 4, 2026. This label includes a boxed warning.

Indications (excerpt from the label)

Safyral is a combination of drospirenone, a progestin and ethinyl estradiol, an estrogen containing a folate, indicated for use by females of reproductive potential to: • Prevent pregnancy. ( 1.1 ) • Raise folate levels in females of reproductive potential who choose to use an oral contraceptive for contraception. ( 1.2 ) 1.1 Oral Contraceptive Safyral is indicated for use by females of reproductive potential to prevent pregnancy. 1.2 Folate Supplementation Safyral is indicated in females of reproductive potential who choose to use an oral contraceptive as their method of contraception, to raise folate levels for the purpose of reducing the risk of a neural tube defect in a pregnancy conceiv…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 50419-403

What is NDC 50419-403?: 50419-403 is the product NDC for Safyral kit, listed with the FDA by Bayer HealthCare Pharmaceuticals Inc.. It has 4 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Safyral (Drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium).
Who is the labeler?: Bayer HealthCare Pharmaceuticals Inc., NDC labeler code 50419. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Safyral?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under NDA 022574

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 022574
Product	Strength	Form · route	Labeler	Product NDC
Drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium	—	Kit	Sandoz Inc	0781-4103