What is NDC 42681-0048?

42681-0048 is the product NDC for 365 Whole Foods Market Spearmint Flavored Fluoride Mouthwash Anticavity, Fluoride ion .1 mg/mL mouthwash, listed with the FDA by WHOLE FOODS. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

365 Whole Foods Market Spearmint Flavored Fluoride Mouthwash Anticavity (Fluoride).

WHOLE FOODS, NDC labeler code 42681. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for 365 Whole Foods Market Spearmint Flavored Fluoride Mouthwash Anticavity?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

NDC 42681-0048

NDC codes

FDA NDC Directory

Product NDC (as listed)42681-0048Labeler and product segments. Claims need a package NDC.

Product NDC at billing width42681-0048Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
42681-0048-1	4268100480142681004801	500 mL in 1 BOTTLE (42681-0048-1)Marketed from May 1, 2026

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): 365 Whole Foods Market Spearmint Flavored Fluoride Mouthwash Anticavity
Generic name (nonproprietary): fluoride
Active ingredients: Fluoride ion — .1 mg/mL
Dosage form: Mouthwash
Route: Oral
Labeler: WHOLE FOODSNDC labeler code 42681
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 022
Marketing start: Mar 31, 2026
Listing expires: Dec 31, 2027
Identifiers: Product ID 42681-0048_5105135c-ec41-9f20-e063-6394a90aeb41SPL ID 5105135c-ec41-9f20-e063-6394a90aeb41SPL set ID 25bc7ab1-116d-143a-e063-6394a90aa970RxCUI 313029UNII Q80VPU408O

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N442681004801 followed by a unit qualifier and the quantity

Package 42681-0048-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective May 4, 2026.

Indications (excerpt from the label)

Use Aids in the prevention of dental cavities

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 42681-0048

What is NDC 42681-0048?: 42681-0048 is the product NDC for 365 Whole Foods Market Spearmint Flavored Fluoride Mouthwash Anticavity, Fluoride ion .1 mg/mL mouthwash, listed with the FDA by WHOLE FOODS. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: 365 Whole Foods Market Spearmint Flavored Fluoride Mouthwash Anticavity (Fluoride).
What is the active ingredient?: Fluoride ion.
Who is the labeler?: WHOLE FOODS, NDC labeler code 42681. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for 365 Whole Foods Market Spearmint Flavored Fluoride Mouthwash Anticavity?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under M 022

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 022
Product	Strength	Form · route	Labeler	Product NDC
3ECARE Dual formula WhiteningToothpaste Refillsodium fluoride	Sodium fluoride .155 g/100g	OintmentSubgingival	Hangzhou Namei Zhikang Technology Co., Ltd.	87514-002
3x Medicated Mouth Sore Gelbenzocaine	Zinc chloride .15 g/100g + 2 more ingredients	GelOral	Walgreens	0363-1605
3X Medicated Mouth Sore Gelbenzocaine	Benzocaine 20 g/100g + 2 more ingredients	GelOral	Rite Aid	11822-6170
3x Medicated Mouth Sore Gelbenzocaine	Menthol, Unspecified form .1 g/100g + 2 more ingredients	GelOral	HEB	37808-691
3x Medicated Mouth Sore Gelbenzocaine	Benzocaine 20 g/100g + 2 more ingredients	GelOral	CVS	69842-660
3x Medicated Toothache and Gum Gelbenzocaine	Benzocaine 20 g/100g + 2 more ingredients	GelOral	CVS	69842-693
4-in-1 Teeth Care Pens	Sodium fluoride .25 g/100g	Gel, DentifriceTopical	Jiangxi Dentalbright Technology Co., Ltd	83778-011
4X Medicated Severe Toothache and Gum Creambenzocaine	Benzocaine 20 g/100g + 3 more ingredients	CreamOral	Rite Aid	11822-0614
4X Medicated Severe Toothache and Gum Gelbenzocaine	Benzalkonium chloride .13 g/100g + 3 more ingredients	GelOral	Rite Aid	11822-0615
4x Medicated Toothache and Gum Creambenzocaine	Benzocaine 20 g/100g + 3 more ingredients	CreamOral	HEB	37808-116
4x Medicated Toothache and Gum Creambenzocaine	Benzalkonium chloride .13 g/100g + 3 more ingredients	CreamOral	CVS	69842-631
4x Medicated Toothache and Gum Gelbenzocaine	Menthol, Unspecified form .5 g/100g + 3 more ingredients	GelOral	Walgreens	0363-6008
4X Medicated Toothache and Gum Gelbenzocaine	Benzocaine 20 g/100g + 3 more ingredients	GelOral	Walmart	49035-569
4x Medicated Toothache and Gum Gelbenzocaine	Benzocaine 20 g/100g + 3 more ingredients	Gel, DentifriceOral	Publix Super Markets INC	56062-312
4x Medicated Toothache and Gum Gelbenzocaine	Benzalkonium chloride .13 g/100g + 3 more ingredients	GelOral	CVS	69842-642
7 Select Oral Pain Maximum Strength Reliefbenzocaine	Benzocaine 200 mg/g	GelTopical	7-ELEVEN, INC.	10202-853
ABC Sore Throat Menthol Flavorphenol	Phenol 1.4 g/100mL	SprayOral	AMERISOURCE BERGEN	46122-749
Acetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	NuCare Pharmaceuticals,Inc.	68071-4860
Advance Topical Anesthetic Gelbenzocaine	Benzocaine 200 mg/g	GelDental	The Atlanta Dental Supply Company DBA Advanced Dental Products	71347-100
Advance Topical Anesthetic Gelbenzocaine	Benzocaine 200 mg/g	GelDental	The Atlanta Dental Supply Company DBA Advanced Dental Products	71347-101

Showing 20 of 39.

365 Whole Foods Market Spearmint Flavored Fluoride Mouthwash Anticavity (Fluoride) NDC 42681-0048