NDC codes

FDA NDC Directory
Product NDC (as listed)42291-426Labeler and product segments. Claims need a package NDC.
Product NDC at billing width42291-0426Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
42291-426-42422910426421 TUBE in 1 CARTON (42291-426-42) / 42.5 g in 1 TUBEMarketed from Feb 16, 2021

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Estradiol Vaginal
Generic name (nonproprietary)
estradiol
Active ingredients
Estradiol — .1 mg/g
Dosage form
Cream
Route
Vaginal
Labeler
AvKARE
Product type
Prescription drug
Marketing category
ANDA — Abbreviated New Drug Application (generic)Application ANDA 210194
Marketing start
Listing expires
Other FDA classes
Estradiol Congeners (Chemical structure)Estrogen Receptor Agonists (Mechanism)
Identifiers
Product ID 42291-426_485cfe5e-2e15-d6a9-e063-6394a90aa303SPL ID 485cfe5e-2e15-d6a9-e063-6394a90aa303SPL set ID bb7b442d-b8c3-b7f0-e053-2a95a90a2c94RxCUI 310169UNII 4TI98Z838E
Pharmacologic class
Estrogen

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

NDC on a medical claim

N442291042642 followed by a unit qualifier and the quantity

Package 42291-0426-42. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective . This label includes a boxed warning.

Indications (excerpt from the label)

INDICATIONS AND USAGE Estradiol Vaginal Cream, 0.01% is indicated in the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under ANDA 210194

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 210194
ProductStrengthForm · routeLabelerProduct NDC
Estradiol VaginalestradiolEstradiol .1 mg/gCreamVaginalNuCare Pharmaceuticals, Inc.68071-3796
Estradiol VaginalestradiolEstradiol .1 mg/gCreamVaginalBryant Ranch Prepack71335-2831
Estradiol VaginalestradiolEstradiol .1 mg/gCreamVaginalBryant Ranch Prepack72162-1389
Estradiol VaginalestradiolEstradiol .1 mg/gCreamVaginalPadagis Israel Pharmaceuticals Ltd45802-097
Estradiol VaginalestradiolEstradiol .1 mg/gCreamVaginalBryant Ranch Prepack63629-8654
Estradiol VaginalestradiolEstradiol .1 mg/gCreamVaginalRedpharm Drug67296-2258
Estradiol VaginalestradiolEstradiol .1 mg/gCreamVaginalA-S Medication Solutions50090-7266

Free account

Keep searching with a free account

You’ve used your 3 free searches for this session. Log in or create a free Med-Code account to keep looking up NDCs, J-codes and drugs.

Create a free accountLog in