What is NDC 25357-025?

25357-025 is the product NDC for Photrexa Cross-linking Kit (riboflavin 5-phosphate ophthalmic) kit, listed with the FDA by Glaukos Corporation. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Photrexa Cross-linking Kit (Riboflavin 5-phosphate ophthalmic).

Glaukos Corporation, NDC labeler code 25357. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Photrexa Cross-linking Kit?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Photrexa Cross-linking Kit NDC 25357-025

NDC codes

FDA NDC Directory

Product NDC (as listed)25357-025Labeler and product segments. Claims need a package NDC.

Product NDC at billing width25357-0025Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
25357-025-03	25357002503	2 POUCH in 1 BOX (25357-025-03) / 1 POUCH in 1 POUCH / 1 SYRINGE, GLASS in 1 POUCH / 1 KIT in 1 SYRINGE, GLASSMarketed from Sep 25, 2017

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Photrexa Cross-linking Kit
Generic name (nonproprietary): riboflavin 5-phosphate ophthalmic
Dosage form: Kit
Labeler: Glaukos CorporationNDC labeler code 25357
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 203324
Marketing start: Sep 25, 2017
Marketing end: Jul 31, 2029
Identifiers: Product ID 25357-025_c945d9a7-2e14-41c7-a209-e537aba21749SPL ID c945d9a7-2e14-41c7-a209-e537aba21749SPL set ID f82cfe92-1a24-11e3-8ffd-0800200c9a66RxCUI 1925825, 1925830

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

NDC on a medical claim

N425357002503 followed by a unit qualifier and the quantity

Package 25357-0025-03. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jul 24, 2026.

Indications (excerpt from the label)

PHOTREXA ® VISCOUS and PHOTREXA ® are indicated for use in corneal collagen cross-linking in combination with the KXL ® System for the treatment of PHOTREXA VISCOUS and PHOTREXA are photoenhancers indicated for use with the KXL System in corneal collagen cross-linking for the treatment of progressive keratoconus ( 1.1 ) and corneal ectasia following refractive surgery ( 1.2 ). 1.1 Progressive Keratoconus 1.2 Corneal Ectasia Following Refractive Surgery

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 25357-025

What is NDC 25357-025?: 25357-025 is the product NDC for Photrexa Cross-linking Kit (riboflavin 5-phosphate ophthalmic) kit, listed with the FDA by Glaukos Corporation. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Photrexa Cross-linking Kit (Riboflavin 5-phosphate ophthalmic).
Who is the labeler?: Glaukos Corporation, NDC labeler code 25357. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Photrexa Cross-linking Kit?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Photrexa Cross-linking Kit (Riboflavin 5-phosphate ophthalmic) NDC 25357-025