What is NDC 25357-024?

25357-024 is the product NDC for Epioxa Cross-Linking (riboflavin 5-phosphate ophthalmic) kit, listed with the FDA by Glaukos Corporation. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Epioxa Cross-Linking (Riboflavin 5-phosphate ophthalmic).

Glaukos Corporation, NDC labeler code 25357. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Epioxa Cross-Linking?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Epioxa Cross-Linking NDC 25357-024 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)25357-024Labeler and product segments. Claims need a package NDC.

Product NDC at billing width25357-0024Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
25357-024-01	25357002401	1 KIT in 1 CARTON (25357-024-01) * 1 SYRINGE, GLASS in 1 POUCH (25357-026-01) / 2 mL in 1 SYRINGE, GLASS * 1 SYRINGE, GLASS in 1 POUCH (25357-027-01) / 2 mL in 1 SYRINGE, GLASSMarketed from Jan 16, 2026

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Epioxa Cross-Linking
Generic name (nonproprietary): riboflavin 5-phosphate ophthalmic
Dosage form: Kit
Route: Ophthalmic
Labeler: Glaukos CorporationNDC labeler code 25357
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 219910
Marketing start: Jan 16, 2026
Listing expires: Dec 31, 2026
Identifiers: Product ID 25357-024_d8f31876-b83b-4535-b2c2-d66210c14b15SPL ID d8f31876-b83b-4535-b2c2-d66210c14b15SPL set ID 13cefc46-337c-41a3-b113-106bfe553bbbRxCUI 2727363, 2727368, 2727371, 2727373, 2727374, 2727375

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Ophthalmic products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N425357002401 followed by a unit qualifier and the quantity

Package 25357-0024-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Nov 18, 2025.

Indications (excerpt from the label)

EPIOXA HD and EPIOXA are indicated in epithelium-on corneal collagen cross-linking for the treatment of keratoconus in adults and pediatric patients aged 13 years and older, in conjunction with the O 2 n System and the Boost Goggles. EPIOXA HD and EPIOXA are photoenhancers indicated for use in epithelium-on corneal collagen cross-linking for the treatment of keratoconus in adults and pediatric patients aged 13 years and older, in conjunction with the O 2 n System and the Boost Goggles ( 1 ).

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 25357-024

What is NDC 25357-024?: 25357-024 is the product NDC for Epioxa Cross-Linking (riboflavin 5-phosphate ophthalmic) kit, listed with the FDA by Glaukos Corporation. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Epioxa Cross-Linking (Riboflavin 5-phosphate ophthalmic).
Who is the labeler?: Glaukos Corporation, NDC labeler code 25357. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Epioxa Cross-Linking?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Epioxa Cross-Linking (Riboflavin 5-phosphate ophthalmic) NDC 25357-024