NDC codes

FDA NDC Directory
Product NDC (as listed)25021-841Labeler and product segments. Claims need a package NDC.
Product NDC at billing width25021-0841Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
25021-841-10250210841105 AMPULE in 1 CARTON (25021-841-10) / 10 mL in 1 AMPULEMarketed from Jul 16, 2026

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Zyogreen
Generic name (nonproprietary)
indocyanine green
Active ingredients
Indocyanine green — 2.5 mg/mL
Dosage form
Injection, Solution
Route
Interstitial, Intravenous
Product type
Prescription drug
Marketing category
NDA — New Drug ApplicationApplication NDA 218579
Marketing start
Listing expires
Identifiers
Product ID 25021-841_1aa18dd8-8838-4698-b358-6956f8b94929SPL ID 1aa18dd8-8838-4698-b358-6956f8b94929SPL set ID b2de0c9a-0065-4f2c-9983-add39525f3a3UNII IX6J1063HV

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

Administration

Drug administration (CPT 96360–96549)

When a clinician administers the drug, the administration is reported separately. Codes in this range cover hydration, therapeutic injections and infusions, and chemotherapy or other complex drug administration. The right code depends on route, duration and drug type, and self-administered drugs are not billed this way.

How CPT relates to drug billing

NDC on a medical claim

N425021084110 followed by a unit qualifier and the quantity

Package 25021-0841-10. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective .

Indications (excerpt from the label)

ZYOGREEN is an optical imaging agent indicated for: Fluorescence imaging of vessels (micro- and macro-vasculature), blood flow and tissue perfusion before, during and after vascular, gastrointestinal, organ transplant, plastic, micro- and reconstructive surgeries, including general minimally invasive surgical procedures, in adults and pediatric patients ( 1.1 ) Fluorescence imaging of extrahepatic biliary ducts in adults and pediatric patients from birth to less than 1 year of age and 6 years of age and older ( 1.2 ) Fluorescence imaging of lymph nodes and lymphatic vessels during lymphatic mapping in adults with cervical and uterine cancer ( 1.3 ) Ophthalmic angiography in adults and pediat…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

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