What is NDC 25021-181?

25021-181 is the product NDC for Piperacillin, Tazobactam, Piperacillin sodium 36 g/152mL; Tazobactam sodium 4.5 g/152mL injection, powder, lyophilized, for solution, listed with the FDA by Sagent Pharmaceuticals. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Piperacillin, Tazobactam (Piperacillin Sodium, Tazobactam Sodium).

What is the active ingredient?

Piperacillin sodium, Tazobactam sodium.

Sagent Pharmaceuticals, NDC labeler code 25021. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Piperacillin, Tazobactam?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Piperacillin, Tazobactam NDC 25021-181

NDC codes

FDA NDC Directory

Product NDC (as listed)25021-181Labeler and product segments. Claims need a package NDC.

Product NDC at billing width25021-0181Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
25021-181-99	25021018199	1 BOTTLE in 1 CARTON (25021-181-99) / 152 mL in 1 BOTTLEMarketed from Feb 28, 2021

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Piperacillin, Tazobactam
Generic name (nonproprietary): piperacillin sodium, tazobactam sodium
Active ingredients: Piperacillin sodium — 36 g/152mLTazobactam sodium — 4.5 g/152mL
Dosage form: Injection, Powder, Lyophilized, For solution
Route: Intravenous
Labeler: Sagent PharmaceuticalsNDC labeler code 25021
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 208675
Marketing start: Feb 28, 2021
Listing expires: Dec 31, 2026
Other FDA classes: Penicillins (Chemical structure)beta Lactamase Inhibitors (Mechanism)
Identifiers: Product ID 25021-181_a6724256-14c5-4408-83a5-a964f146f0d5SPL ID a6724256-14c5-4408-83a5-a964f146f0d5SPL set ID 83f4adcd-893c-4e9e-8f2b-e06299dcf34dRxCUI 312447UNII M98T69Q7HP, UXA545ABTT
Pharmacologic class: Penicillin-class Antibacterial; beta Lactamase Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

Administration

Drug administration (CPT 96360–96549)

When a clinician administers the drug, the administration is reported separately. Codes in this range cover hydration, therapeutic injections and infusions, and chemotherapy or other complex drug administration. The right code depends on route, duration and drug type, and self-administered drugs are not billed this way.

How CPT relates to drug billing

NDC on a medical claim

N425021018199 followed by a unit qualifier and the quantity

Package 25021-0181-99. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Aug 31, 2024.

Indications (excerpt from the label)

Piperacillin and Tazobactam for Injection is a combination of piperacillin, a penicillin-class antibacterial and tazobactam, a beta-lactamase inhibitor, indicated for the treatment of: Intra-abdominal infections in adult and pediatric patients 2 months of age and older ( 1.1 ) Nosocomial pneumonia in adult and pediatric patients 2 months of age and older ( 1.2 ) Skin and skin structure infections in adults ( 1.3 ) Female pelvic infections in adults ( 1.4 ) Community-acquired pneumonia in adults ( 1.5 ) To reduce the development of drug-resistant bacteria and maintain the effectiveness of Piperacillin and Tazobactam for Injection and other antibacterial drugs, piperacillin and tazobactam shou…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 25021-181

What is NDC 25021-181?: 25021-181 is the product NDC for Piperacillin, Tazobactam, Piperacillin sodium 36 g/152mL; Tazobactam sodium 4.5 g/152mL injection, powder, lyophilized, for solution, listed with the FDA by Sagent Pharmaceuticals. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Piperacillin, Tazobactam (Piperacillin Sodium, Tazobactam Sodium).
What is the active ingredient?: Piperacillin sodium, Tazobactam sodium.
Who is the labeler?: Sagent Pharmaceuticals, NDC labeler code 25021. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Piperacillin, Tazobactam?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Piperacillin, Tazobactam (Piperacillin sodium, tazobactam sodium) NDC 25021-181