What is NDC 21922-108?

21922-108 is the product NDC for Halobetasol Propionate, Halobetasol propionate .5 mg/g ointment, listed with the FDA by Encube Ethicals, Inc.. It has 2 package NDCs, shown above in 10- and 11-digit form.

Encube Ethicals, Inc., NDC labeler code 21922. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Halobetasol Propionate?

13 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Halobetasol Propionate NDC 21922-108 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)21922-108Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21922-0108Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21922-108-04	21922010804	1 TUBE in 1 CARTON (21922-108-04) / 15 g in 1 TUBEMarketed from Jul 1, 2026
21922-108-14	21922010814	1 TUBE in 1 CARTON (21922-108-14) / 50 g in 1 TUBEMarketed from Jul 1, 2026

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Halobetasol Propionate
Generic name (nonproprietary): halobetasol propionate
Active ingredients: Halobetasol propionate — .5 mg/g
Dosage form: Ointment
Route: Topical
Labeler: Encube Ethicals, Inc.NDC labeler code 21922
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 209978
Marketing start: Jul 1, 2026
Listing expires: Dec 31, 2027
Other FDA classes: Corticosteroid Hormone Receptor Agonists (Mechanism)
Identifiers: Product ID 21922-108_b933ad2a-8b48-4127-a66b-aa70024a02c3SPL ID b933ad2a-8b48-4127-a66b-aa70024a02c3SPL set ID d4f03a79-3d5e-4a39-8ab0-8ebd3d804e39RxCUI 977978UNII 91A0K1TY3Z
Pharmacologic class: Corticosteroid

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Topical products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421922010804 followed by a unit qualifier and the quantity

Package 21922-0108-04. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jun 29, 2026.

Indications (excerpt from the label)

INDICATIONS AND USAGE Halobetasol propionate ointment, 0.05% is a super-high potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. Treatment beyond two consecutive weeks is not recommended, and the total dosage should not exceed 50 g/week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Use in children under 12 years of age is not recommended. As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of the diagnosis may be necessary.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 21922-108

What is NDC 21922-108?: 21922-108 is the product NDC for Halobetasol Propionate, Halobetasol propionate .5 mg/g ointment, listed with the FDA by Encube Ethicals, Inc.. It has 2 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Halobetasol Propionate.
What is the active ingredient?: Halobetasol propionate.
Who is the labeler?: Encube Ethicals, Inc., NDC labeler code 21922. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Halobetasol Propionate?: 13 other product NDCs are listed under this name. See all Halobetasol Propionate NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Halobetasol Propionate NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Halobetasol Propionate	Halobetasol propionate .5 mg/g	LotionTopical	Coral Way Pharma, LLC	85437-008	85437-0008-60
Halobetasol propionate	Halobetasol propionate .5 mg/g	Aerosol, FoamTopical	Mayne Pharma	68308-769	68308-0769-50
Halobetasol Propionate	Halobetasol propionate .5 mg/g	OintmentTopical	QUAGEN PHARMACEUTICALS LLC	70752-119	70752-0119-0270752-0119-04
Halobetasol Propionate	Halobetasol propionate .5 mg/g	OintmentTopical	Bryant Ranch Prepack	72162-2067	72162-2067-0272162-2067-04
Halobetasol Propionate	Halobetasol propionate .5 mg/g	OintmentTopical	Bryant Ranch Prepack	72162-1396	72162-1396-0272162-1396-04
Halobetasol Propionate	Halobetasol propionate .5 mg/g	OintmentTopical	Padagis Israel Pharmaceuticals Ltd	45802-131	45802-0131-3245802-0131-35
Halobetasol Propionate	Halobetasol propionate .5 mg/g	OintmentTopical	Bryant Ranch Prepack	63629-8664	63629-8664-01
Halobetasol Propionate	Halobetasol propionate .5 mg/g	OintmentTopical	Bryant Ranch Prepack	63629-8665	63629-8665-01
Halobetasol Propionate	Halobetasol propionate .5 mg/g	CreamTopical	Padagis Israel Pharmaceuticals Ltd	45802-129	45802-0129-3245802-0129-35
Halobetasol Propionate	Halobetasol propionate .5 mg/g	CreamTopical	Bryant Ranch Prepack	72162-2331	72162-2331-02

All 14 Halobetasol Propionate NDCs