NDC 21922-052

NDC codes

FDA NDC Directory

Product NDC (as listed)21922-052Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21922-0052Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21922-052-50	21922005250	1 BOTTLE, PUMP in 1 CARTON (21922-052-50) / 45 g in 1 BOTTLE, PUMPMarketed from Aug 14, 2023

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Adapalene and Benzoyl Peroxide Gel, 0.1%/2.5%
Generic name (nonproprietary): adapalene and benzoyl peroxide gel, 0.1%/2.5%
Active ingredients: Adapalene — 1 mg/gBenzoyl peroxide — 25 mg/g
Dosage form: Gel
Route: Topical
Labeler: Encube Ethicals, Inc.
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 206164
Marketing start: Aug 14, 2023
Listing expires: Dec 31, 2027
Other FDA classes: Retinoids (Chemical structure)
Identifiers: Product ID 21922-052_977e8df9-820f-4b8f-bfe2-da1b72ca93c7SPL ID 977e8df9-820f-4b8f-bfe2-da1b72ca93c7SPL set ID 66858a82-cfda-4ba9-aac7-cf65499f4b1aRxCUI 829539UNII 1L4806J2QF, W9WZN9A0GM
Pharmacologic class: Retinoid

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Topical products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421922005250 followed by a unit qualifier and the quantity

Package 21922-0052-50. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jun 15, 2026.

Indications (excerpt from the label)

Adapalene and benzoyl peroxide gel USP, 0.1% / 2.5% is indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. Adapalene and benzoyl peroxide gel USP, 0.1% / 2.5% is a combination of adapalene, a retinoid, and benzoyl peroxide, and is indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. (1)

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under ANDA 206164

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 206164
Product	Strength	Form · route	Labeler	Product NDC
Adapalene and Benzoyl Peroxide Gel, 0.1%/2.5%	Adapalene 1 mg/g; Benzoyl peroxide 25 mg/g	GelTopical	Bryant Ranch Prepack	72162-2296

Adapalene and Benzoyl Peroxide Gel, 0.1%/2.5% NDC 21922-052