Adapalene Gel USP, 0.3% NDC 21922-051

NDC codes

FDA NDC Directory

Product NDC (as listed)21922-051Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21922-0051Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21922-051-06	21922005106	1 TUBE in 1 CARTON (21922-051-06) / 45 g in 1 TUBEMarketed from Aug 10, 2023
21922-051-50	21922005150	1 BOTTLE, PUMP in 1 CARTON (21922-051-50) / 45 g in 1 BOTTLE, PUMPMarketed from Aug 10, 2023

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Adapalene Gel USP, 0.3%
Generic name (nonproprietary): adapalene gel usp, 0.3%
Active ingredients: Adapalene — 3 mg/g
Dosage form: Gel
Route: Topical
Labeler: Encube Ethicals, Inc.
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 200298
Marketing start: Aug 7, 2023
Listing expires: Dec 31, 2026
Other FDA classes: Retinoids (Chemical structure)
Identifiers: Product ID 21922-051_2e5f2180-7624-4bb6-892d-e63491da2591SPL ID 2e5f2180-7624-4bb6-892d-e63491da2591SPL set ID 56045eee-e84d-467a-9e12-e62bd474ed8aRxCUI 722111UNII 1L4806J2QF
Pharmacologic class: Retinoid

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Topical products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421922005106 followed by a unit qualifier and the quantity

Package 21922-0051-06. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Sep 4, 2025.

Indications (excerpt from the label)

ADAPALENE Gel, 0.3% is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. ADAPALENE Gel, 0.3% is a retinoid, indicated for the topical treatment of acne vulgaris in patients 12 years of age and older.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under ANDA 200298

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 200298
Product	Strength	Form · route	Labeler	Product NDC
Adapalene Gel USP, 0.3%	Adapalene 3 mg/g	GelTopical	Bryant Ranch Prepack	72162-2295