What is NDC 21922-004?

21922-004 is the product NDC for Desonide Ointment, 0.05%, Desonide .5 mg/g ointment, listed with the FDA by Encube Ethicals, Inc.. It has 2 package NDCs, shown above in 10- and 11-digit form.

Encube Ethicals, Inc., NDC labeler code 21922. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Desonide Ointment, 0.05%?

3 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Desonide Ointment, 0.05% NDC 21922-004

NDC codes

FDA NDC Directory

Product NDC (as listed)21922-004Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21922-0004Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21922-004-04	2192200040421922000404	1 TUBE in 1 CARTON (21922-004-04) / 15 g in 1 TUBEMarketed from Mar 20, 2019
21922-004-07	2192200040721922000407	1 TUBE in 1 CARTON (21922-004-07) / 60 g in 1 TUBEMarketed from Mar 20, 2019

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Desonide Ointment, 0.05%
Generic name (nonproprietary): desonide ointment, 0.05%
Active ingredients: Desonide — .5 mg/g
Dosage form: Ointment
Route: Topical
Labeler: Encube Ethicals, Inc.NDC labeler code 21922
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 210998
Marketing start: Mar 20, 2019
Listing expires: Dec 31, 2027
Other FDA classes: Corticosteroid Hormone Receptor Agonists (Mechanism)
Identifiers: Product ID 21922-004_545fde77-f6c2-4129-b67f-1f8eadd5efdeSPL ID 545fde77-f6c2-4129-b67f-1f8eadd5efdeSPL set ID 3d4d19d4-e47b-407e-9df4-fed5f3db91b9RxCUI 204135UNII J280872D1OUPC 0321922004076, 0321922004045
Pharmacologic class: Corticosteroid

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Topical products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421922000404 followed by a unit qualifier and the quantity

Package 21922-0004-04. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Mar 9, 2026.

Indications (excerpt from the label)

INDICATIONS AND USAGE Desonide ointment USP, 0.05% is a low potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. It should not be used for longer than two weeks unless directed by a physician.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 21922-004

What is NDC 21922-004?: 21922-004 is the product NDC for Desonide Ointment, 0.05%, Desonide .5 mg/g ointment, listed with the FDA by Encube Ethicals, Inc.. It has 2 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Desonide Ointment, 0.05%.
What is the active ingredient?: Desonide.
Who is the labeler?: Encube Ethicals, Inc., NDC labeler code 21922. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Desonide Ointment, 0.05%?: 3 other product NDCs are listed under this name. See all Desonide Ointment, 0.05% NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Desonide Ointment, 0.05% NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Desonide Ointment, 0.05%	Desonide .5 mg/g	OintmentTopical	Bryant Ranch Prepack	63629-8481	63629-8481-01
Desonide Ointment, 0.05%	Desonide .5 mg/g	OintmentTopical	Bryant Ranch Prepack	63629-8482	63629-8482-01
Desonide Ointment, 0.05%	Desonide .5 mg/g	OintmentTopical	Bryant Ranch Prepack	72162-1272	72162-1272-0272162-1272-06

Other NDCs under ANDA 210998

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 210998
Product	Strength	Form · route	Labeler	Product NDC
Desonide Ointment, 0.05%	Desonide .5 mg/g	OintmentTopical	Bryant Ranch Prepack	63629-8481
Desonide Ointment, 0.05%	Desonide .5 mg/g	OintmentTopical	Bryant Ranch Prepack	63629-8482
Desonide Ointment, 0.05%	Desonide .5 mg/g	OintmentTopical	Bryant Ranch Prepack	72162-1272