What is NDC 21220-158?

21220-158 is the product NDC for Helium/Oxygen Mixture 70/30, Oxygen 300 mL/L gas, listed with the FDA by General Air Service & Supply Co. It has 2 package NDCs, shown above in 10- and 11-digit form.

General Air Service & Supply Co, NDC labeler code 21220. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Helium/Oxygen Mixture 70/30?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Helium/Oxygen Mixture 70/30 NDC 21220-158

NDC codes

FDA NDC Directory

Product NDC (as listed)21220-158Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21220-0158Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21220-158-01	21220015801	7108 L in 1 CYLINDER (21220-158-01)Marketed from Jan 1, 1975
21220-158-02	21220015802	708 L in 1 CYLINDER (21220-158-02)Marketed from Jan 1, 1975

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Helium/Oxygen Mixture 70/30
Generic name (nonproprietary): helium/oxygen mixture 70/30
Active ingredients: Oxygen — 300 mL/L
Dosage form: Gas
Route: Respiratory (Inhalation)
Labeler: General Air Service & Supply CoNDC labeler code 21220
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 205849
Marketing start: Jan 1, 1975
Listing expires: Dec 31, 2026
Identifiers: Product ID 21220-158_44876125-3917-ecfd-e063-6294a90a2260SPL ID 44876125-3917-ecfd-e063-6294a90a2260SPL set ID 620d5fe1-f7f1-8de7-e053-2a91aa0a8664UNII S88TT14065

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

NDC on a medical claim

N421220015801 followed by a unit qualifier and the quantity

Package 21220-0158-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Nov 26, 2025.

Full label on DailyMed (opens in a new tab)

About NDC 21220-158

What is NDC 21220-158?: 21220-158 is the product NDC for Helium/Oxygen Mixture 70/30, Oxygen 300 mL/L gas, listed with the FDA by General Air Service & Supply Co. It has 2 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Helium/Oxygen Mixture 70/30.
What is the active ingredient?: Oxygen.
Who is the labeler?: General Air Service & Supply Co, NDC labeler code 21220. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Helium/Oxygen Mixture 70/30?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under NDA 205849

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 205849
Product	Strength	Form · route	Labeler	Product NDC
Oxygen	Oxygen 995 mL/L	GasRespiratory (Inhalation)	Toll Company	82457-004
Oxygen	Oxygen 99 L/100L	GasRespiratory (Inhalation)	Biomedics Systems, Inc.	72574-001
Oxygen	Oxygen 991 mL/L	GasRespiratory (Inhalation)	NexAir, LLC	12213-720
Oxygen	Oxygen 992 mL/L	GasRespiratory (Inhalation)	Central-McGowan, Inc.	10221-001
Nitrogen Oxygen Mix	Oxygen 210 mL/L	GasRespiratory (Inhalation)	NexAir, LLC	12213-733
Carbon Dioxide/Oxygen Mix	Oxygen 50 mL/L	GasRespiratory (Inhalation)	NEXAIR, LLC	12213-800
Oxygen	Oxygen 99 L/100L	GasRespiratory (Inhalation)	James Supplies, L.L.c	50505-001
Helium/Oxygen Mix	Oxygen 200 mL/L	GasRespiratory (Inhalation)	NEXAIR, LLC	12213-801
Oxygen	Oxygen 995 mL/L	GasRespiratory (Inhalation)	General Air Service & Supply Co	21220-119
Oxygen Nitrogen Mixture	Oxygen 200 mL/L	GasRespiratory (Inhalation)	General Air Service & Supply Co.	21220-130
Air	Oxygen 210 mL/L	GasRespiratory (Inhalation)	General Air Service & Supply Co	21220-152
Helium/Oxygen Mixture 80/20	Oxygen 200 mL/L	GasRespiratory (Inhalation)	General Air Service & Supply Co.	21220-155
Carbon Dioxide Oxygen Mixture	Oxygen 800 mL/L	GasRespiratory (Inhalation)	General Air Service & Supply Co	21220-156
Oxygen	Oxygen 99 L/100L	GasRespiratory (Inhalation)	RTA Pediatric Care Inc.	69241-001
Oxygen	Oxygen 99 L/100L	GasRespiratory (Inhalation)	Gilmore Liquid Air Co.	51012-001
Oxygen	Oxygen 995 mL/L	GasRespiratory (Inhalation)	General Cryogenic Technologies LLC	21221-002
Oxygen	Oxygen 990 mL/L	GasRespiratory (Inhalation)	DuPuy Oxygen & Supply Company, Inc.	50554-100
Oxygen	Oxygen 990 mL/L	GasRespiratory (Inhalation)	T.W. Smith Corp.	52563-005
Oxygen	Oxygen 99 L/100L	GasRespiratory (Inhalation)	Holston Gases, Inc.	55050-0011
Oxygen	Oxygen 1 L/L	GasRespiratory (Inhalation)	Empresas De Soldaduras	80421-100

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