What is NDC 21220-157?

21220-157 is the product NDC for Carbon Dioxide Air Mixture, Carbon dioxide 50 mL/L gas, listed with the FDA by General Air Service & Supply Co. It has 2 package NDCs, shown above in 10- and 11-digit form.

General Air Service & Supply Co, NDC labeler code 21220. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Carbon Dioxide Air Mixture?

4 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Carbon Dioxide Air Mixture NDC 21220-157

NDC codes

FDA NDC Directory

Product NDC (as listed)21220-157Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21220-0157Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21220-157-01	21220015701	6597 L in 1 CYLINDER (21220-157-01)Marketed from Jan 1, 1975
21220-157-02	21220015702	651 L in 1 CYLINDER (21220-157-02)Marketed from Jan 1, 1975

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Carbon Dioxide Air Mixture
Generic name (nonproprietary): carbon dioxide air mixture
Active ingredients: Carbon dioxide — 50 mL/L
Dosage form: Gas
Route: Respiratory (Inhalation)
Labeler: General Air Service & Supply CoNDC labeler code 21220
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 205852
Marketing start: Jan 1, 1975
Listing expires: Dec 31, 2026
Other FDA classes: X-Ray Contrast Activity (Mechanism)
Identifiers: Product ID 21220-157_44875fd6-d209-f99e-e063-6294a90a4a73SPL ID 44875fd6-d209-f99e-e063-6294a90a4a73SPL set ID 620d4f99-cba6-5f7f-e053-2a91aa0a3000RxCUI 309002UNII 142M471B3J
Pharmacologic class: Radiographic Contrast Agent

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

NDC on a medical claim

N421220015701 followed by a unit qualifier and the quantity

Package 21220-0157-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Nov 26, 2025.

Full label on DailyMed (opens in a new tab)

About NDC 21220-157

What is NDC 21220-157?: 21220-157 is the product NDC for Carbon Dioxide Air Mixture, Carbon dioxide 50 mL/L gas, listed with the FDA by General Air Service & Supply Co. It has 2 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Carbon Dioxide Air Mixture.
What is the active ingredient?: Carbon dioxide.
Who is the labeler?: General Air Service & Supply Co, NDC labeler code 21220. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Carbon Dioxide Air Mixture?: 4 other product NDCs are listed under this name. See all Carbon Dioxide Air Mixture NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Carbon Dioxide Air Mixture NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Carbon Dioxide-Air Mixture	Carbon dioxide 70 mL/L; Oxygen 210 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-016	46123-0016-01
Carbon Dioxide-Air Mixture	Carbon dioxide 50 mL/L; Oxygen 210 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-115	46123-0115-0146123-0115-0246123-0115-03+2 more
Carbon Dioxide-Air Mixture	Carbon dioxide 80 mL/L; Oxygen 210 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-117	46123-0117-0146123-0117-02
Carbon Dioxide-Air Mixture	Carbon dioxide 100 mL/L; Oxygen 210 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-181	46123-0181-0146123-0181-0246123-0181-03

Other NDCs under NDA 205852

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 205852
Product	Strength	Form · route	Labeler	Product NDC
Carbon Dioxide	Carbon dioxide 990 mL/L	GasRespiratory (Inhalation)	Linde Inc.	59578-125
Carbon Dioxide	Carbon dioxide 990 mL/L	GasRespiratory (Inhalation)	Linde Gas & Equipment Inc.	59579-003
Carbon Dioxide	Carbon dioxide 990 mL/L	GasRespiratory (Inhalation)	ILMO Products Company	51486-005
Carbon Dioxide	Carbon dioxide 990 mL/L	GasRespiratory (Inhalation)	Oxarc, LLC	34057-501