What is NDC 21220-155?

21220-155 is the product NDC for Helium/Oxygen Mixture 80/20, Oxygen 200 mL/L gas, listed with the FDA by General Air Service & Supply Co.. It has 2 package NDCs, shown above in 10- and 11-digit form.

General Air Service & Supply Co., NDC labeler code 21220. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Helium/Oxygen Mixture 80/20?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Helium/Oxygen Mixture 80/20 NDC 21220-155

NDC codes

FDA NDC Directory

Product NDC (as listed)21220-155Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21220-0155Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21220-155-01	21220015501	7108 L in 1 CYLINDER (21220-155-01)Marketed from Jan 1, 1975
21220-155-02	21220015502	708 L in 1 CYLINDER (21220-155-02)Marketed from Jan 1, 1975

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Helium/Oxygen Mixture 80/20
Generic name (nonproprietary): helium/oxygen mixture 80/20
Active ingredients: Oxygen — 200 mL/L
Dosage form: Gas
Route: Respiratory (Inhalation)
Labeler: General Air Service & Supply Co.NDC labeler code 21220
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 205849
Marketing start: Jan 1, 1975
Listing expires: Dec 31, 2026
Identifiers: Product ID 21220-155_44875fd6-d207-f99e-e063-6294a90a4a73SPL ID 44875fd6-d207-f99e-e063-6294a90a4a73SPL set ID 60df34a1-e3fa-6959-e053-2a91aa0a4760RxCUI 413101UNII S88TT14065

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

NDC on a medical claim

N421220015501 followed by a unit qualifier and the quantity

Package 21220-0155-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Nov 26, 2025.

Full label on DailyMed (opens in a new tab)

About NDC 21220-155

What is NDC 21220-155?: 21220-155 is the product NDC for Helium/Oxygen Mixture 80/20, Oxygen 200 mL/L gas, listed with the FDA by General Air Service & Supply Co.. It has 2 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Helium/Oxygen Mixture 80/20.
What is the active ingredient?: Oxygen.
Who is the labeler?: General Air Service & Supply Co., NDC labeler code 21220. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Helium/Oxygen Mixture 80/20?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under NDA 205849

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 205849
Product	Strength	Form · route	Labeler	Product NDC
Air	Oxygen 210 mL/L	GasRespiratory (Inhalation)	General Air Service & Supply Co	21220-152
Air	Oxygen 210 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-109
Carbon Dioxide Oxygen Mix	Carbon dioxide 300 mL/L; Oxygen 700 mL/L	GasRespiratory (Inhalation)	Linde Gas & Equipment Inc.	59579-008
Carbon Dioxide Oxygen Mixture	Oxygen 800 mL/L	GasRespiratory (Inhalation)	General Air Service & Supply Co	21220-156
Carbon Dioxide-Air Mixture	Carbon dioxide 70 mL/L; Oxygen 210 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-016
Carbon Dioxide-Air Mixture	Carbon dioxide 50 mL/L; Oxygen 210 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-115
Carbon Dioxide-Air Mixture	Carbon dioxide 80 mL/L; Oxygen 210 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-117
Carbon Dioxide-Air Mixture	Carbon dioxide 100 mL/L; Oxygen 210 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-181
Carbon Dioxide-Oxygen Mixture	Carbon dioxide 70 mL/L; Oxygen 930 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-120
Carbon Dioxide-Oxygen Mixture	Carbon dioxide 150 mL/L; Oxygen 850 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-123
Carbon Dioxide-Oxygen Mixture	Carbon dioxide 200 mL/L; Oxygen 800 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-124
Carbon Dioxide-Oxygen Mixture	Carbon dioxide 100 mL/L; Oxygen 900 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-521
Carbon Dioxide-Oxygen Mixture	Oxygen 880 mL/L; Carbon dioxide 120 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-522
Carbon Dioxide-Oxygen Mixture	Carbon dioxide 50 mL/L; Oxygen 950 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-911
Carbon Dioxide-Oxygen-Nitrogen Mixture	Oxygen 50 mL/L; Carbon dioxide 200 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-535
Carbon Dioxide-Oxygen-Nitrogen Mixture	Oxygen 210 mL/L; Carbon dioxide 70 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-536
Carbon Dioxide-Oxygen-Nitrogen Mixture	Oxygen 350 mL/L; Carbon dioxide 50 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-537
Carbon Dioxide-Oxygen-Nitrogen Mixture	Oxygen 400 mL/L; Carbon dioxide 50 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-538
Carbon Dioxide-Oxygen-Nitrogen Mixture	Oxygen 450 mL/L; Carbon dioxide 50 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-539
Carbon Dioxide-Oxygen-Nitrogen Mixture	Oxygen 330 mL/L; Carbon dioxide 70 mL/L	GasRespiratory (Inhalation)	Roberts Oxygen Company, Inc.	46123-540

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