What is NDC 21130-703?

21130-703 is the product NDC for Signature Care Eye Drops Redness and Dry Eye Relief, Glycerin .25 g/100mL; Naphazoline hydrochloride .012 g/100mL solution/ drops, listed with the FDA by Better Living Brands LLC. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Signature Care Eye Drops Redness and Dry Eye Relief (Glycerin, Naphazoline hydrochloride).

What is the active ingredient?

Glycerin, Naphazoline hydrochloride.

Better Living Brands LLC, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Signature Care Eye Drops Redness and Dry Eye Relief?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

NDC 21130-703

NDC codes

FDA NDC Directory

Product NDC (as listed)21130-703Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21130-0703Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21130-703-01	2113007030121130070301	1 BOTTLE, PLASTIC in 1 CARTON (21130-703-01) / 15 mL in 1 BOTTLE, PLASTICMarketed from Oct 5, 2018

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Signature Care Eye Drops Redness and Dry Eye Relief
Generic name (nonproprietary): glycerin, naphazoline hydrochloride
Active ingredients: Glycerin — .25 g/100mLNaphazoline hydrochloride — .012 g/100mL
Dosage form: Solution/ drops
Route: Ophthalmic
Labeler: Better Living Brands LLCNDC labeler code 21130
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 018
Marketing start: Oct 5, 2018
Listing expires: Dec 31, 2026
Other FDA classes: Allergens (Chemical structure)Cell-mediated Immunity (Physiologic effect)Glycerol (Chemical structure)Increased Histamine Release (Physiologic effect)Increased IgG Production (Physiologic effect)
Identifiers: Product ID 21130-703_472bb859-5ad3-aad2-e063-6294a90a3b86SPL ID 472bb859-5ad3-aad2-e063-6294a90a3b86SPL set ID 901f3bbe-e1bb-4e44-879c-711e59813a7fRxCUI 1046700UNII PDC6A3C0OX, MZ1131787DUPC 0321130700609
Pharmacologic class: Non-Standardized Chemical Allergen

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Ophthalmic products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421130070301 followed by a unit qualifier and the quantity

Package 21130-0703-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 19, 2025.

Indications (excerpt from the label)

Uses for the relief of redness of the eye due to minor eye irritations for the temporary relief of burining and irritation due to dryness of the eye for use as a protectant against further irritation or dryness of the eye

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 21130-703

What is NDC 21130-703?: 21130-703 is the product NDC for Signature Care Eye Drops Redness and Dry Eye Relief, Glycerin .25 g/100mL; Naphazoline hydrochloride .012 g/100mL solution/ drops, listed with the FDA by Better Living Brands LLC. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Signature Care Eye Drops Redness and Dry Eye Relief (Glycerin, Naphazoline hydrochloride).
What is the active ingredient?: Glycerin, Naphazoline hydrochloride.
Who is the labeler?: Better Living Brands LLC, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Signature Care Eye Drops Redness and Dry Eye Relief?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under M 018

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 018
Product	Strength	Form · route	Labeler	Product NDC
Walgreens Eye Drops Maximum Redness Relief 15mLglycerin, naphazoline hci	Naphazoline hydrochloride .03 g/100mL; Glycerin .5 g/100mL	Solution/ dropsOphthalmic	Walgreen Company	0363-4546
Vista Gonio Eye Lubricanthypromellose ophthalmic solution	Hypromellose 2208 (100 mpa.s) 25 mg/15mL	SolutionOphthalmic	Red Wedding LLC	77790-022
Capasil Pain Relievingmenthol, methyl salicylate	Methyl salicylate 100 mg/mL; Menthol 20 mg/mL	CreamTopical	PureTek Corporation	59088-434
Rugby Eye Washwater, purified	Water 99.05 g/100mL	SolutionOphthalmic	A-S Medication Solutions	50090-7440
DG Original Eye Dropstetrahydrozoline hcl	Tetrahydrozoline hydrochloride .05 g/100mL	SolutionOphthalmic	Dolgencorp LLC	55910-363
TopCare Health Lubricant Eye Dropscarboxymethylcellulose sodium	Carboxymethylcellulose sodium .5 g/100mL	Solution/ dropsOphthalmic	Topcare Associates LLC	76162-089
VitaPhyte Lubricating Eye Dropslubricating eye drops	Carboxymethylcellulose sodium 5 mg/mL; Glycerin 3 mg/mL	SolutionOphthalmic	Guangzhou Liyan Cosmetics Technology Co., Ltd.	87770-008
VISTA Hypromellose Dry Eye Reliefhypromellose	Hypromellose 2910 (50 mpa.s) .3 g/mL	GelOphthalmic	Red Wedding LLC	77790-002
EyS Eye Washwater	Water 14.85 mL/15mL	SolutionOphthalmic	Eyes-Plus LLC	57349-220
DG Health Advanced Relief Eye Dropsdextran 70, polyethylene glycol 400, povidone, tetrahydrozoline hcl	Povidone, Unspecified 1 g/100mL + 3 more ingredients	SolutionOphthalmic	Dolgencorp LLC	55910-361
Fendall 2000 Pure Flowpurified water	Water 98.6 L/100L	LiquidOphthalmic	Honeywell Safety Products USA, Inc.	0498-0631
VISTA MEIBO TEARS Propylene Glycol 0.6% w/v Advanced Dry Eye Relief Lubricating Drops 10 mlpropylene glycol	Propylene glycol .6 g/100mL	LiquidOphthalmic	Red Wedding LLC	77790-003
VitaPhyte Lubricant Eye Dropslubricant eye drops	Carboxymethylcellulose sodium 5 mg/mL; Glycerin 3 mg/mL	SolutionOphthalmic	Guangzhou Liyan Cosmetics Technology Co., Ltd.	87770-020
DG Health Dry Eye Reliefglycerin, hypromellose, polypropylene glycol 400	Polyethylene glycol 400 1 g/100mL + 2 more ingredients	SolutionOphthalmic	Dolgencorp LLC	55910-362
Optaseglycerin	Glycerin 2 mg/mL	Solution/ dropsOphthalmic	Scope Health Inc	72972-002
Rippleglycerin, povidone	Glycerin .63 g/100mL; Povidone .25 g/100mL	Solution/ dropsOphthalmic	CorneaCare Inc	82875-003
Salinenasal	Sodium chloride 6.5 mg/mL	SprayNasal	GERI-CARE PHARMACEUTICAL CORP	57896-333
Signature Care Lubricant Eye Dropscarboxymethylcellulose sodium	Carboxymethylcellulose sodium .5 g/100mL	Solution/ dropsOphthalmic	Better Living Brands LLC	21130-705
Optaseglycerin	Glycerin 1 mg/mL	SprayOphthalmic	Scope Health Inc	72972-001
Discount Drug Mart Eye Drops Multi-Symptom Reliefpolyethylene glycol 400, tetrahydrozoline hcl, zinc sulfate	Zinc sulfate .25 g/100mL + 2 more ingredients	Solution/ dropsOphthalmic	Discount Drug Mart, Inc.	53943-490

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Signature Care Eye Drops Redness and Dry Eye Relief (Glycerin, naphazoline hydrochloride) NDC 21130-703