What is NDC 21130-661?

21130-661 is the product NDC for Acetaminophen and Diphenhydramine HCL, Acetaminophen 500 mg/1; Diphenhydramine 25 mg/1 tablet, listed with the FDA by SAFEWAY. It has 3 package NDCs, shown above in 10- and 11-digit form.

What is the active ingredient?

Acetaminophen, Diphenhydramine.

SAFEWAY, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Acetaminophen and Diphenhydramine HCL?

1 other product NDC are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Acetaminophen and Diphenhydramine HCL NDC 21130-661

NDC codes

FDA NDC Directory

Product NDC (as listed)21130-661Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21130-0661Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package
21130-661-10	21130066110	100 TABLET in 1 BOTTLE (21130-661-10)Marketed from Jun 30, 2023
21130-661-20	21130066120	200 TABLET in 1 BOTTLE (21130-661-20)Marketed from Jun 30, 2023
21130-661-24	21130066124	24 TABLET in 1 BOTTLE (21130-661-24)Marketed from Jun 30, 2023

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Acetaminophen and Diphenhydramine HCL
Generic name (nonproprietary): acetaminophen and diphenhydramine hcl
Active ingredients: Acetaminophen — 500 mg/1Diphenhydramine — 25 mg/1
Dosage form: Tablet
Route: Oral
Labeler: SAFEWAYNDC labeler code 21130
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 013
Marketing start: Jun 30, 2023
Listing expires: Dec 31, 2026
Other FDA classes: Histamine H1 Receptor Antagonists (Mechanism)
Identifiers: Product ID 21130-661_4650a298-b556-8c7e-e063-6394a90a01dbSPL ID 4650a298-b556-8c7e-e063-6394a90a01dbSPL set ID f18c1aa2-5f8b-5458-e053-2995a90ab947RxCUI 1092189UNII 362O9ITL9D, 8GTS82S83M
Pharmacologic class: Histamine-1 Receptor Antagonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421130066110 followed by a unit qualifier and the quantity

Package 21130-0661-10. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 19, 2025.

Indications (excerpt from the label)

Uses temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 21130-661

What is NDC 21130-661?: 21130-661 is the product NDC for Acetaminophen and Diphenhydramine HCL, Acetaminophen 500 mg/1; Diphenhydramine 25 mg/1 tablet, listed with the FDA by SAFEWAY. It has 3 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Acetaminophen and Diphenhydramine HCL.
What is the active ingredient?: Acetaminophen, Diphenhydramine.
Who is the labeler?: SAFEWAY, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Acetaminophen and Diphenhydramine HCL?: 1 other product NDC are listed under this name. See all Acetaminophen and Diphenhydramine HCL NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Acetaminophen and Diphenhydramine HCL NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Acetaminophen and Diphenhydramine HCL	Diphenhydramine 25 mg/1; Acetaminophen 500 mg/1	TabletOral	PUBLIX SUPERMARKETS, INC	41415-661	41415-0661-0541415-0661-10

Other NDCs under M 013

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 013
Product	Strength	Form · route	Labeler	Product NDC
Best Choice Effervescent Pain Reliever 36aspirin	Aspirin 325 mg/1	Tablet, EffervescentOral	VALU MERCHANDISERS COMPANY	63941-241
Aspirin Packsaspirin	Aspirin 325 mg/1	Tablet, Film coatedOral	Sina Health Inc	70385-2006
Back and Body Extra Strengthaspirin, caffeine	Aspirin 500 mg/1; Caffeine 32.5 mg/1	Tablet, Film coatedOral	Cardinal Health 110, LLC. DBA Leader	70000-0127
foster and thrive aspirinaspirin	Aspirin 81 mg/1	Tablet, ChewableOral	Strategic Sourcing Services LLC	70677-1134
Medique Pain Offacetaminophen, aspirin, caffeine	Caffeine 65 mg/1 + 2 more ingredients	Tablet, Film coatedOral	Unifirst First Aid Corporation	47682-238
Acetaminophen Extra Strengthacetaminophen	Acetaminophen 500 mg/1	Tablet, Film coatedOral	Wal-Mart Stores Inc	49035-175
Low Dose Aspirinaspirin	Aspirin 81 mg/1	Tablet, CoatedOral	A-S Medication Solutions	50090-4830
Childrens Pain Relief	Acetaminophen 160 mg/5mL	LiquidOral	Allegiant Health	69168-455
Aspirin Low Doseaspirin	Aspirin 81 mg/1	Tablet, CoatedOral	MAJOR PHARMACEUTICALS	0904-6783
equaline acetaminophenacetaminophen	Acetaminophen 500 mg/1	TabletOral	United Natural Foods, Inc. dba UNFI	41163-363
Chewable Aspirinaspirin	Aspirin 81 mg/1	Tablet, ChewableOral	HARRIS TEETER	72036-205
Pain Relief PM Extra Strengthacetaminophen and diphenhydramine hydrochloride	Acetaminophen 500 mg/1; Diphenhydramine hydrochloride 25 mg/1	Tablet, CoatedOral	Chain Drug Marketing Association	63868-325
Excedrin Extra Strength and Excedrin Tension Headacheacetaminophen, aspirin (nsaid), and caffeine	—	Kit	Haleon US Holdings LLC	0067-8151
Enteric Coated Aspirin Regular Strengthaspirin	Aspirin 325 mg/1	Tablet, Delayed releaseOral	Safeway	21130-081
Headache Relief Extra Strengthacetaminophen, aspirin, caffeine	Acetaminophen 250 mg/1 + 2 more ingredients	TabletOral	H E B	37808-586
DrKids Childrens Pain and Feveracetaminophen 80mg/piece	Acetaminophen 80 mg/1	Bar, ChewableOral	CalmCo LLC	73282-2480
CAREALL Non-Aspirin PM Extra Strengthacetaminophen, diphenhydramine hcl	Acetaminophen 500 mg/1; Diphenhydramine hydrochloride 25 mg/1	TabletOral	New World Imports, Inc	51824-069
dg health pain reliefacetaminophen	Acetaminophen 500 mg/1	TabletOral	Dolgencorp Inc	55910-661
Extra Strength Acetaminophenacetaminophen	Acetaminophen 500 mg/1	TabletOral	Preferred Pharmaceuticals Inc.	68788-4065
Aspirin 81mg Dye-Freeaspirin 81mg	Aspirin 81 mg/1	Tablet, Film coatedOral	Allegiant Health	69168-457

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