NDC codes

FDA NDC Directory
Product NDC (as listed)0456-1201Labeler and product segments. Claims need a package NDC.
Product NDC at billing width00456-1201Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
0456-1201-04004561201041 BOTTLE in 1 CARTON (0456-1201-04) / 4 CAPSULE, GELATIN COATED in 1 BOTTLEMarketed from Sep 8, 2012 · Sample package
0456-1201-07004561201071 BOTTLE in 1 CARTON (0456-1201-07) / 7 CAPSULE, GELATIN COATED in 1 BOTTLEMarketed from May 17, 2019 · Sample package
0456-1201-30004561201301 BOTTLE in 1 CARTON (0456-1201-30) / 30 CAPSULE, GELATIN COATED in 1 BOTTLEMarketed from Sep 8, 2012

How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Linzess
Generic name (nonproprietary)
linaclotide
Active ingredients
Linaclotide — 145 ug/1
Dosage form
Capsule, Gelatin coated
Route
Oral
Labeler
Allergan, Inc.NDC labeler code 0456
Product type
Prescription drug
Marketing category
NDA — New Drug ApplicationApplication NDA 202811
Marketing start
Listing expires
Other FDA classes
Guanylate Cyclase Activators (Mechanism)
Identifiers
Product ID 0456-1201_621456b5-c1a3-48b8-99ac-ccbf8beebf43SPL ID 621456b5-c1a3-48b8-99ac-ccbf8beebf43SPL set ID 09beda19-56d6-4a56-afdc-9a77b70b2ef3RxCUI 1307409, 1307415, 1307419, 1307421, 1869697, 1869699UNII N0TXR0XR5XUPC 0304561203307, 0304561202300, 0304561201303
Pharmacologic class
Guanylate Cyclase-C Agonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N400456120104 followed by a unit qualifier and the quantity

Package 00456-1201-04. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective . This label includes a boxed warning.

Indications (excerpt from the label)

LINZESS is indicated for the treatment of: • irritable bowel syndrome with constipation (IBS-C) in adults and pediatric patients 7 years of age and older • chronic idiopathic constipation (CIC) in adults • functional constipation (FC) in pediatric patients 2 years of age and older LINZESS is a guanylate cyclase-C agonist indicated for treatment of: Irritable bowel syndrome with constipation (IBS-C) in adults and pediatric patients 7 years of age and older. ( 1 ) Chronic idiopathic constipation (CIC) in adults. ( 1 ) Functional constipation (FC) in pediatric patients 2 years of age and older. ( 1 )

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 0456-1201

What is NDC 0456-1201?
0456-1201 is the product NDC for Linzess (linaclotide), Linaclotide 145 ug/1 capsule, gelatin coated, listed with the FDA by Allergan, Inc.. It has 3 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?
Linzess (Linaclotide).
What is the active ingredient?
Linaclotide.
Who is the labeler?
Allergan, Inc., NDC labeler code 0456. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Linzess?
2 other product NDCs are listed under this name. See all Linzess NDCs.
Is there a related HCPCS / J-code?
Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Linzess NDCs
ProductStrengthForm · routeLabelerProduct NDCPackage NDCs (11-digit)
LinzesslinaclotideLinaclotide 72 ug/1Capsule, Gelatin coatedOralAllergan, Inc.0456-120300456-1203-0400456-1203-0700456-1203-30
LinzesslinaclotideLinaclotide 290 ug/1Capsule, Gelatin coatedOralAllergan, Inc.0456-120200456-1202-0400456-1202-0700456-1202-30

Other NDCs under NDA 202811

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 202811
ProductStrengthForm · routeLabelerProduct NDC
LinzesslinaclotideLinaclotide 290 ug/1Capsule, Gelatin coatedOralAllergan, Inc.0456-1202
LinzesslinaclotideLinaclotide 72 ug/1Capsule, Gelatin coatedOralAllergan, Inc.0456-1203

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