What is NDC 0280-1400?

0280-1400 is the product NDC for Alka-Seltzer Plus Cold Medicine Sparkling Original, Aspirin 325 mg/1 + 2 more ingredients tablet, effervescent, listed with the FDA by Bayer HealthCare LLC.. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Alka-Seltzer Plus Cold Medicine Sparkling Original (ASPIRIN, CHLORPHENIRAMINE MALEATE, and PHENYLEPHRINE BITARTRATE).

What is the active ingredient?

Aspirin, Chlorpheniramine maleate, Phenylephrine bitartrate.

Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Alka-Seltzer Plus Cold Medicine Sparkling Original?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

NDC 0280-1400

NDC codes

FDA NDC Directory

Product NDC (as listed)0280-1400Labeler and product segments. Claims need a package NDC.

Product NDC at billing width00280-1400Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
0280-1400-32	0028014003200280140032	16 POUCH in 1 CARTON (0280-1400-32) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Apr 10, 2008

How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Alka-Seltzer Plus Cold Medicine Sparkling Original
Generic name (nonproprietary): aspirin, chlorpheniramine maleate, and phenylephrine bitartrate
Active ingredients: Aspirin — 325 mg/1Chlorpheniramine maleate — 2 mg/1Phenylephrine bitartrate — 7.8 mg/1
Dosage form: Tablet, Effervescent
Route: Oral
Labeler: Bayer HealthCare LLC.NDC labeler code 0280
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 013
Marketing start: Apr 10, 2008
Listing expires: Dec 31, 2026
Other FDA classes: Adrenergic alpha1-Agonists (Mechanism)Non-Steroidal (Chemical structure)Cyclooxygenase Inhibitors (Mechanism)Decreased Platelet Aggregation (Physiologic effect)Decreased Prostaglandin Production (Physiologic effect)Histamine H1 Receptor Antagonists (Mechanism)
Identifiers: Product ID 0280-1400_4526711d-1058-262c-e063-6294a90aef61SPL ID 4526711d-1058-262c-e063-6294a90aef61SPL set ID 78537dcf-b157-4b67-a8b2-5cb144815166RxCUI 1536840UNII R16CO5Y76E, V1Q0O9OJ9Z, 27O3Q5ML57
Pharmacologic class: Histamine-1 Receptor Antagonist; Nonsteroidal Anti-inflammatory Drug; Platelet Aggregation Inhibitor; alpha-1 Adrenergic Agonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N400280140032 followed by a unit qualifier and the quantity

Package 00280-1400-32. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 4, 2025.

Indications (excerpt from the label)

Uses temporarily relieves these symptoms due to a cold: temporarily reduces fever

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 0280-1400

What is NDC 0280-1400?: 0280-1400 is the product NDC for Alka-Seltzer Plus Cold Medicine Sparkling Original, Aspirin 325 mg/1 + 2 more ingredients tablet, effervescent, listed with the FDA by Bayer HealthCare LLC.. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Alka-Seltzer Plus Cold Medicine Sparkling Original (ASPIRIN, CHLORPHENIRAMINE MALEATE, and PHENYLEPHRINE BITARTRATE).
What is the active ingredient?: Aspirin, Chlorpheniramine maleate, Phenylephrine bitartrate.
Who is the labeler?: Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Alka-Seltzer Plus Cold Medicine Sparkling Original?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under M 013

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 013
Product	Strength	Form · route	Labeler	Product NDC
Acetaminophen	Acetaminophen 500 mg/1	Tablet, CoatedOral	COSTCO WHOLESALE CORPORATION	63981-019
Extra Strength Pain Releifacetaminophen	Acetaminophen 500 mg/1	Tablet, Film coatedOral	Strategic Sourcing Services, LLC	70677-1242
Aspirin 81 mgaspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	H E B	37808-600
TYLENOL Extra Strengthacetaminophen	Acetaminophen 500 mg/1	Tablet, Film coatedOral	Morning Star OTC	53209-1001
Extra Strength Pain Relieveracetaminophen tablets 500 mg	Acetaminophen 500 mg/1	TabletOral	WALGREENS	0363-0669
Pain Relieveracetaminophen capsules 500mg (minis-red opaque)	Acetaminophen 500 mg/1	Capsule, Liquid filledOral	Walgreens	0363-6684
Mommys Bliss Childrens Pain and Feveracetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Mom Enterprises, LLC.	71444-793
Childrens Pain and Feveracetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	CVS Pharmacy	59779-126
Good Neighbor Pharmacy childrens pain and feveracetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Amerisource Bergen	46122-211
Acetaminophen	Acetaminophen 160 mg/5mL	LiquidOral	A-S Medication Solutions	50090-6059
Members Mark Acetaminophenacetaminophen	Acetaminophen 500 mg/1	TabletOral	Sam's West Inc	68196-606
Mommys Bliss Infants Pain and Feveracetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Mom Enterprises, LLC.	71444-893
Thompson Extra Strength Non-Aspirinacetaminophen	Acetaminophen 500 mg/1	TabletOral	Thompson	73408-174
Aspirin 81 mg Low Doseaspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	CHAIN DRUG MARKETING ASSOCIATION, INC.	83324-089
Acetaminophen	Acetaminophen 500 mg/1	TabletOral	ASCLEMED USA INC.	87063-222
Pain Relief Aspirin Low Doseaspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	Rite Aid Corporation	11822-0600
equate pain and fever childrensacetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Wal-Mart Stores Inc	49035-042
Pain and Fever Childrensacetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	P & L Development, LLC	49580-0282
Dye Free Pain and Fever Childrensacetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Walgreens	0363-0285
Pain Reliever Extra Strengthacetaminophen	Acetaminophen 500 mg/1	Tablet, CoatedOral	Walgreen Company	0363-0519

Showing 20 of 40.

Alka-Seltzer Plus Cold Medicine Sparkling Original NDC 0280-1400