What is NDC 0280-0160?

0280-0160 is the product NDC for Alka-Seltzer Heartburn and Pain, Anhydrous citric acid 1000 mg/1 + 2 more ingredients tablet, effervescent, listed with the FDA by Bayer HealthCare LLC.. It has 5 package NDCs, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Alka-Seltzer Heartburn and Pain (ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE).

What is the active ingredient?

Anhydrous citric acid, Aspirin, Sodium bicarbonate.

Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Alka-Seltzer Heartburn and Pain?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Alka-Seltzer Heartburn and Pain NDC 0280-0160

NDC codes

FDA NDC Directory

Product NDC (as listed)0280-0160Labeler and product segments. Claims need a package NDC.

Product NDC at billing width00280-0160Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package
0280-0160-01	0028001600100280016001	58 POUCH in 1 CARTON (0280-0160-01) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Feb 3, 2025
0280-0160-02	0028001600200280016002	6 POUCH in 1 CARTON (0280-0160-02) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Feb 3, 2025
0280-0160-03	0028001600300280016003	12 POUCH in 1 CARTON (0280-0160-03) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Feb 3, 2025
0280-0160-04	0028001600400280016004	18 POUCH in 1 CARTON (0280-0160-04) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Feb 3, 2025
0280-0160-05	0028001600500280016005	36 POUCH in 1 CARTON (0280-0160-05) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Feb 3, 2025

How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Alka-Seltzer Heartburn and Pain
Generic name (nonproprietary): anhydrous citric acid, aspirin, and sodium bicarbonate
Active ingredients: Anhydrous citric acid — 1000 mg/1Aspirin — 325 mg/1Sodium bicarbonate — 1916 mg/1
Dosage form: Tablet, Effervescent
Route: Oral
Labeler: Bayer HealthCare LLC.NDC labeler code 0280
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 013
Marketing start: Feb 3, 2025
Listing expires: Dec 31, 2026
Other FDA classes: Acidifying Activity (Mechanism)Alkalinizing Activity (Mechanism)Non-Steroidal (Chemical structure)Calcium Chelating Activity (Mechanism)Cyclooxygenase Inhibitors (Mechanism)Decreased Coagulation Factor Activity (Physiologic effect)Decreased Platelet Aggregation (Physiologic effect)Decreased Prostaglandin Production (Physiologic effect)
Identifiers: Product ID 0280-0160_2928e140-c867-5bf5-e063-6394a90ab024SPL ID 2928e140-c867-5bf5-e063-6394a90ab024SPL set ID 2928e140-c868-5bf5-e063-6394a90ab024RxCUI 1536675UNII XF417D3PSL, R16CO5Y76E, 8MDF5V39QO
Pharmacologic class: Anti-coagulant; Calculi Dissolution Agent; Nonsteroidal Anti-inflammatory Drug; Platelet Aggregation Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N400280016001 followed by a unit qualifier and the quantity

Package 00280-0160-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 13, 2024.

Indications (excerpt from the label)

Uses For the temporary relief of minor aches and pains with heartburn, sour stomach, or acid indigestion and upset stomach associated with these symptoms for temporary relief of headaches, body aches, backache and pain alone

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 0280-0160

What is NDC 0280-0160?: 0280-0160 is the product NDC for Alka-Seltzer Heartburn and Pain, Anhydrous citric acid 1000 mg/1 + 2 more ingredients tablet, effervescent, listed with the FDA by Bayer HealthCare LLC.. It has 5 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Alka-Seltzer Heartburn and Pain (ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE).
What is the active ingredient?: Anhydrous citric acid, Aspirin, Sodium bicarbonate.
Who is the labeler?: Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Alka-Seltzer Heartburn and Pain?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under M 013

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 013
Product	Strength	Form · route	Labeler	Product NDC
Aspirin Low Doseaspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	ATLANTIC BIOLOGICALS CORP.	17856-3086
Childrens TYLENOLacetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Kenvue Brands LLC	50580-614
Acetaminophen Regular strengthacetaminophen	Acetaminophen 325 mg/1	TabletOral	PD-Rx Pharmaceuticals, Inc.	55289-563
Pain Reliever PM Extra Strengthacetaminophen, diphenhydramine hcl	Acetaminophen 500 mg/1; Diphenhydramine hydrochloride 25 mg/1	Tablet, CoatedOral	TOP CARE (Topco Associates LLC)	36800-466
Acetaminophen 325 Mgacetaminophen	Acetaminophen 325 mg/1	TabletOral	Proficient Rx LP	71205-456
Acetaminophen	Acetaminophen 500 mg/1	Tablet, CoatedOral	Harris Teeter	72036-170
Topcare Aspirinaspirin	Aspirin 81 mg/1	Tablet, ChewableOral	Topco Associates LLC	36800-467
Pain Reliefacetaminophen	Acetaminophen 500 mg/1	Tablet, CoatedOral	HYVEE INC	42507-592
Pain Relief Extra Strengthacetaminophen	Acetaminophen 500 mg/1	Tablet, CoatedOral	MARC GLASSMAN, INC.	68998-392
Acetaminophen	Acetaminophen 500 mg/1	TabletOral	Trifecta Pharmaceuticals USA LLC	69396-140
Goodnow Pain Reliefacetaminophen	Acetaminophen 500 mg/1	TabletOral	Gobrands, Inc	82501-0484
Tension Headache Pain Relieving Aidacetaminophen,caffeine	Acetaminophen 500 mg/1; Caffeine 65 mg/1	TabletOral	WAL-MART STORES INC	79903-373
Acetaminophen , Aspirin and Caffeine	Aspirin 250 mg/1 + 2 more ingredients	CapsuleOral	Softgel Healthcare Pvt Ltd	35916-0709
Acetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	PAI Holdings, LLC dba PAI Pharma	0121-0941
CareOne Childrens Acetaminophenacetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	American Sales Company	41520-615
Childrens TYLENOLacetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Kenvue Brands LLC	50580-612
Adwe Feverx Acetaminophen Caplets, 500 mg Extra Strengthacetaminophen	Acetaminophen 500 mg/1	TabletOral	Aurex Laboratories Limited Liability Company	71009-109
Acetaminophen PMacetaminophen and diphenhydramine hydrochloride	Acetaminophen 500 mg/1; Diphenhydramine hydrochloride 25 mg/1	Tablet, CoatedOral	Harris Teeter	72036-171
Basic Care Childrens Pain and Feveracetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Amazon.com Services LLC	72288-130
good neighbor pharmacy aspirinaspirin	Aspirin 81 mg/1	Tablet, ChewableOral	Amerisource Bergen	24385-278

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