What is NDC 0280-0103?

0280-0103 is the product NDC for Bayer Rapid Relief (aspirin/caffeine oral powder), Caffeine 65 mg/1; Aspirin 650 mg/1 powder, listed with the FDA by Bayer HealthCare LLC.. It has 3 package NDCs, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Bayer Rapid Relief (Aspirin/Caffeine Oral Powder).

Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Bayer Rapid Relief?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Bayer Rapid Relief NDC 0280-0103 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)0280-0103Labeler and product segments. Claims need a package NDC.

Product NDC at billing width00280-0103Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package
0280-0103-01	00280010301	1 PACKET in 1 CARTON (0280-0103-01) / 10 POWDER in 1 PACKETMarketed from Jan 13, 2023
0280-0103-02	00280010302	1 PACKET in 1 CARTON (0280-0103-02) / 20 POWDER in 1 PACKETMarketed from Jan 13, 2023
0280-0103-03	00280010303	1 PACKET in 1 CARTON (0280-0103-03) / 30 POWDER in 1 PACKETMarketed from Jan 13, 2023

How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Bayer Rapid Relief
Generic name (nonproprietary): aspirin/caffeine oral powder
Active ingredients: Caffeine — 65 mg/1Aspirin — 650 mg/1
Dosage form: Powder
Route: Oral
Labeler: Bayer HealthCare LLC.NDC labeler code 0280
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 013
Marketing start: Jan 13, 2023
Listing expires: Dec 31, 2026
Other FDA classes: Non-Steroidal (Chemical structure)Central Nervous System Stimulation (Physiologic effect)Cyclooxygenase Inhibitors (Mechanism)Decreased Platelet Aggregation (Physiologic effect)Decreased Prostaglandin Production (Physiologic effect)Xanthines (Chemical structure)
Identifiers: Product ID 0280-0103_45372de8-2f8f-007c-e063-6294a90a4f7bSPL ID 45372de8-2f8f-007c-e063-6294a90a4f7bSPL set ID f1fecbb0-5b55-fe8f-e053-2995a90a0977RxCUI 2626726UNII 3G6A5W338E, R16CO5Y76EUPC 0312843597631
Pharmacologic class: Central Nervous System Stimulant; Methylxanthine; Nonsteroidal Anti-inflammatory Drug; Platelet Aggregation Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N400280010301 followed by a unit qualifier and the quantity

Package 00280-0103-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 5, 2025.

Indications (excerpt from the label)

Uses temporarily relieves minor aches and pains due to: • headache • muscle pain • backache • menstrual cramps • minor pain of arthritis • temporarily reduces feve

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 0280-0103

What is NDC 0280-0103?: 0280-0103 is the product NDC for Bayer Rapid Relief (aspirin/caffeine oral powder), Caffeine 65 mg/1; Aspirin 650 mg/1 powder, listed with the FDA by Bayer HealthCare LLC.. It has 3 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Bayer Rapid Relief (Aspirin/Caffeine Oral Powder).
What is the active ingredient?: Caffeine, Aspirin.
Who is the labeler?: Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Bayer Rapid Relief?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under M 013

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 013
Product	Strength	Form · route	Labeler	Product NDC
Calmour Childrens Acetaminophen Strips Chewableacetaminophen oral chewable 80 mg	Acetaminophen 80 mg/1	StripOral	Calmour	82918-006
Acetaminophen and Diphenhydramine HCL	Diphenhydramine 25 mg/1; Acetaminophen 500 mg/1	TabletOral	PUBLIX SUPERMARKETS, INC	41415-661
Clear Choice Regular Strength Pain Relieveracetaminophen	Acetaminophen 325 mg/1	TabletOral	Athlete's Needs, Inc.	53185-005
Acetaminophen (Red)acetaminophen	Acetaminophen 325 mg/1	Capsule, Liquid filledOral	Humanwell PuraCap Pharmaceutical (Wuhan), Ltd.	53345-010
Pain Relief PMacetaminophen, aspirin, diphenhydramine citrate	Acetaminophen 250 mg/1 + 2 more ingredients	Tablet, Film coatedOral	CVS Pharmacy	59779-894
Childrens Pain and Feveracetaminophen	Acetaminophen 160 mg/5mL	LiquidOral	Marc Glassman, Inc.	68998-525
Children Acetaminophen Oral Solutionacetaminophen	Acetaminophen 160 mg/5mL	LiquidOral	MAJOR PHARMACEUTICALS	0904-7014
signature care childrens pain reliefacetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Safeway	21130-243
Aspirin 81mg Adult Low Doseaspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	TopCare	36800-880
Green Guard Maximum Strength Non-Aspirinacetaminophen	Acetaminophen 500 mg/1	Tablet, Film coatedOral	Unifirst First Aid Corporation	47682-619
Aspirin	Aspirin 325 mg/1	Tablet, Delayed releaseOral	Amerisource Bergen	46122-596
Aspirin Low Doseaspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	A-S Medication Solutions	50090-6928
equate childrens pain and feveracetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Wal-Mart Stores Inc	49035-959
Pain Reliefacetaminophen	Acetaminophen 500 mg/1	Tablet, CoatedOral	DISCOUNT DRUG MART	53943-298
Pain Reliever PM Extra Strengthacetaminophen, diphenhydramine hcl	Acetaminophen 500 mg/1; Diphenhydramine hydrochloride 25 mg/1	Tablet, CoatedOral	Walgreen Company	0363-0556
Cafizetamol Forteacetaminophen, caffeine	Acetaminophen 500 mg/1; Caffeine 65 mg/1	Tablet, Film coatedOral	OPMX LLC	69729-147
Acetaminophen	Acetaminophen 500 mg/1	TabletOral	PUBLIX SUPERMARKETS, INC	41415-538
Low Dose Aspirinaspirin	Aspirin 81 mg/1	Tablet, CoatedOral	Hy-Vee	42507-006
Aspirin 81aspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	Amerisource Bergen	46122-598
Aspirin Low Doseaspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	A-S Medication Solutions	50090-6929

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Bayer Rapid Relief (Aspirin/caffeine oral powder) NDC 0280-0103