Nexium (esomeprazole magnesium) NDC 0186-4025

NDC codes

FDA NDC Directory

Product NDC (as listed)0186-4025Labeler and product segments. Claims need a package NDC.

Product NDC at billing width00186-4025Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
0186-4025-01	00186402501	30 GRANULE, DELAYED RELEASE in 1 CARTON (0186-4025-01)Marketed from Sep 5, 2012

How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Nexium
Generic name (nonproprietary): esomeprazole magnesium
Active ingredients: Esomeprazole magnesium trihydrate — 2.5 mg/1
Dosage form: Granule, Delayed release
Route: Oral
Labeler: AstraZeneca Pharmaceuticals LP
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 021957
Marketing start: Jun 1, 2012
Listing expires: Dec 31, 2027
Other FDA classes: Cytochrome P450 2C19 Inhibitors (Mechanism)Proton Pump Inhibitors (Mechanism)
Identifiers: Product ID 0186-4025_26f66e74-b652-4b1d-bfff-62a3cc87d590SPL ID 26f66e74-b652-4b1d-bfff-62a3cc87d590SPL set ID f4853677-1622-4037-688b-fdf533a11d96RxCUI 606726, 606728, 606730, 606731, 692576, 692578, 861568, 861570, 861576, 861583, 1297658, 1297660, 1297761, 1297763UNII R6DXU4WAY9
Pharmacologic class: Proton Pump Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N400186402501 followed by a unit qualifier and the quantity

Package 00186-4025-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 19, 2025.

Indications (excerpt from the label)

NEXIUM is a proton pump inhibitor (PPI). NEXIUM delayed-release capsules and NEXIUM for delayed-release oral suspension are indicated for the: • Short-term treatment in the healing of erosive esophagitis (EE) in adults and pediatric patients 12 years to 17 years of age. ( 1.1 ) • Maintenance of healing of EE in adults. ( 1.2 ) • Short-term treatment of heartburn and other symptoms associated GERD in adults and pediatric patients 12 years to 17 years of age. ( 1.3 ) • Risk reduction of nonsteroidal anti-inflammatory drugs (NSAID)-associated gastric ulcer in adults at risk for developing gastric ulcers due to age (60 years and older) and/or documented history of gastric ulcers. ( 1.4 ) • Helic…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under NDA 021957

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 021957
Product	Strength	Form · route	Labeler	Product NDC
Nexiumesomeprazole magnesium	Esomeprazole magnesium trihydrate 20 mg/1	Granule, Delayed releaseOral	AstraZeneca Pharmaceuticals LP	0186-4020
Nexiumesomeprazole magnesium	Esomeprazole magnesium trihydrate 40 mg/1	Granule, Delayed releaseOral	AstraZeneca Pharmaceuticals LP	0186-4040
Nexiumesomeprazole magnesium	Esomeprazole magnesium trihydrate 5 mg/1	Granule, Delayed releaseOral	AstraZeneca Pharmaceuticals LP	0186-4050