In short

Vykoura is billed under HCPCS J0644 — Injection, leucovorin calcium (avyxa), 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 3 Vykoura NDCs under this code.

J0644 code details

Reference

J0644
Injection, leucovorin calcium (avyxa), 1 mgBilling unit: 1 mg
Labelers
Avyxa Pharma, LLC

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$2.625
Per1 mg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Added October 2026. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Vykoura units and claim line

Enter the dose given to get the J0644 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Vykoura NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Vykoura NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
83831-0147-05J0644Avyxa Pharma, LLC550
83831-0148-35J0644Avyxa Pharma, LLC35350
83831-0149-50J0644Avyxa Pharma, LLC50500

Vykoura: common questions

What is the J-code for Vykoura?
Vykoura is billed under HCPCS J0644 — Injection, leucovorin calcium (avyxa), 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 3 Vykoura NDCs under this code.
How many J0644 billing units are in a package of Vykoura?
CMS lists 50 to 500 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.
Is J0644 a CPT code?
No. J0644 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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