How many J1325 billing units are in a package of Epoprostenol?

CMS lists 1 to 3 billing units per package, depending on the NDC, where one unit is 0.5 mg. Units to report are based on the dose given, not the package.

No. J1325 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Epoprostenol J-Code J1325 — Billing Units & NDCs

In short

Epoprostenol is billed under HCPCS J1325 — Injection, epoprostenol, 0.5 mg. One billing unit is 0.5 mg. CMS's crosswalk lists 4 Epoprostenol NDCs under this code.

J1325 code details

Reference

J1325: Injection, epoprostenol, 0.5 mgBilling unit: 0.5 mg
Labelers: Mylan Institutional LLC; Sun Pharmaceutical Industries, Inc.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$17.247

Per0.5 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Epoprostenol units and claim line

Enter the dose given to get the J1325 units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 0.5 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

Epoprostenol NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Epoprostenol NDCs in the CMS ASP crosswalk
NDC (11-digit)	HCPCS	Labeler	Package	Billing units per package
62756-0059-40	J1325	Sun Pharmaceutical Industries, Inc.	1	1
62756-0060-40	J1325	Sun Pharmaceutical Industries, Inc.	1	3
67457-0587-10	J1325	Mylan Institutional LLC	1	1
67457-0588-10	J1325	Mylan Institutional LLC	1	3

Epoprostenol: common questions

What is the J-code for Epoprostenol?: Epoprostenol is billed under HCPCS J1325 — Injection, epoprostenol, 0.5 mg. One billing unit is 0.5 mg. CMS's crosswalk lists 4 Epoprostenol NDCs under this code.
How many J1325 billing units are in a package of Epoprostenol?: CMS lists 1 to 3 billing units per package, depending on the NDC, where one unit is 0.5 mg. Units to report are based on the dose given, not the package.
Is J1325 a CPT code?: No. J1325 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Epoprostenol J-Code / HCPCS Code