In short

Depo-Estradiol is billed under HCPCS J1000 — Injection, depo-estradiol cypionate, up to 5 mg. One billing unit is 5 mg. CMS's crosswalk lists 1 Depo-Estradiol NDC under this code.

J1000 code details

Reference

J1000
Injection, depo-estradiol cypionate, up to 5 mgBilling unit: 5 mg
Labelers
Pfizer Inc

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$53.805
Per5 mg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Depo-Estradiol units and claim line

Enter the dose given to get the J1000 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Depo-Estradiol NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Depo-Estradiol NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
00009-0271-01J1000Pfizer Inc55

Depo-Estradiol: common questions

What is the J-code for Depo-Estradiol?
Depo-Estradiol is billed under HCPCS J1000 — Injection, depo-estradiol cypionate, up to 5 mg. One billing unit is 5 mg. CMS's crosswalk lists 1 Depo-Estradiol NDC under this code.
How many J1000 billing units are in a package of Depo-Estradiol?
CMS lists 5 billing units per package, depending on the NDC, where one unit is 5 mg. Units to report are based on the dose given, not the package.
Is J1000 a CPT code?
No. J1000 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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