Oxytocin Reduces Methamphetamine Cravings
Discover how oxytocin enhances adult hippocampal neurogenesis to attenuate methamphetamine-associated reward memories and reduce cravings in patients.
Executive Brief
- The News: Oxytocin enhances adult hippocampal neurogenesis in mice
- Clinical Win: Oxytocin attenuates methamphetamine-associated reward memories
- Target Specialty: Psychiatrists treating methamphetamine dependence
Key Data at a Glance
Condition: Methamphetamine dependence
Key Mechanism: Adult hippocampal neurogenesis
Treatment: Oxytocin
Effect on Memories: Attenuation of methamphetamine-associated reward memories
Species: Mice
Brain Region: Hippocampus
Oxytocin Reduces Methamphetamine Cravings
Morley KC, Cornish JL, Faingold A, Wood K, Haber PS. Pharmacotherapeutic agents in the treatment of methamphetamine dependence. Expert Opin Investig Drugs. 2017;26:563–78.
Bauml KT, Trissl L. Selective memory retrieval can revive forgotten memories. Proc Natl Acad Sci USA. 2022;119:e2114377119.
Keyes PC, Adams EL, Chen Z, Bi L, Nachtrab G, Wang VJ, et al. Orchestrating opiate-associated memories in thalamic circuits. Neuron. 2020;107:1113–23 e1114.
Tsai ST, Liew HK, Li HM, Lin SZ, Chen SY. Harnessing neurogenesis and neuroplasticity with stem cell treatment for addictive disorders. Cell Transpl. 2019;28:1127–31.
Che X, Bai Y, Cai J, Liu Y, Li Y, Yin M, et al. Hippocampal neurogenesis interferes with extinction and reinstatement of methamphetamine-associated reward memory in mice. Neuropharmacology. 2021;196:108717.
Toni N, Schinder AF. Maturation and functional integration of new granule cells into the adult hippocampus. Cold Spring Harb Perspect Biol. 2015;8:a018903.
Toni N, Teng EM, Bushong EA, Aimone JB, Zhao C, Consiglio A, et al. Synapse formation on neurons born in the adult hippocampus. Nat Neurosci. 2007;10:727–34.
Toni N, Laplagne DA, Zhao C, Lombardi G, Ribak CE, Gage FH, et al. Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci. 2008;11:901–7.
Josselyn SA, Tonegawa S. Memory engrams: recalling the past and imagining the future. Science. 2020;367:eaaw4325.
Akers KG, Martinez-Canabal A, Restivo L, Yiu AP, De Cristofaro A, Hsiang HL, et al. Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science. 2014;344:598–602.
Roy DS, Muralidhar S, Smith LM, Tonegawa S. Silent memory engrams as the basis for retrograde amnesia. Proc Natl Acad Sci USA. 2017;114:E9972–E9979.
Wang C, Yue H, Hu Z, Shen Y, Ma J, Li J, et al. Microglia mediate forgetting via complement-dependent synaptic elimination. Science. 2020;367:688–94.
Ko SY, Frankland PW. Neurogenesis-dependent transformation of hippocampal engrams. Neurosci Lett. 2021;762:136176.
Guskjolen A, Kenney JW, de la Parra J, Yeung BA, Josselyn SA, Frankland PW. Recovery of “Lost” infant memories in mice. Curr Biol. 2018;28:2283–90.e2283.
Lopez-Oropeza G, Duran P, Martinez-Canabal A. Maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation. Front Behav Neurosci. 2022;16:971359.
Vasudevan K, Hassell JE Jr, Maren S. Hippocampal engrams and contextual memory. Adv Neurobiol. 2024;38:45–66.
Zhou Y, Zhu H, Liu Z, Chen X, Su X, Ma C, et al. A ventral CA1 to nucleus accumbens core engram circuit mediates conditioned place preference for cocaine. Nat Neurosci. 2019;22:1986–99.
Trouche S, Perestenko PV, van de Ven GM, Bratley CT, McNamara CG, Campo-Urriza N, et al. Recoding a cocaine-place memory engram to a neutral engram in the hippocampus. Nat Neurosci. 2016;19:564–7.
Qi S, Tan SM, Wang R, Higginbotham JA, Ritchie JL, Ibarra CK, et al. Optogenetic inhibition of the dorsal hippocampus CA3 region during early-stage cocaine-memory reconsolidation disrupts subsequent context-induced cocaine seeking in rats. Neuropsychopharmacology. 2022;47:1473–83.
Xia L, Nygard SK, Sobczak GG, Hourguettes NJ, Bruchas MR. Dorsal-CA1 hippocampal neuronal ensembles encode nicotine-reward contextual associations. Cell Rep. 2017;19:2143–56.
Clinical Perspective — Dr. Mohit Joshi, Psychiatry
Workflow: As I manage patients with methamphetamine dependence, I'd consider oxytocin's potential to attenuate reward memories, which could change my approach to treating these patients. According to Che et al., hippocampal neurogenesis interferes with extinction and reinstatement of methamphetamine-associated reward memory in mice, so I'd be interested in exploring oxytocin's role in this process. This could lead to new avenues for treatment and recovery.
Economics: The article doesn't address cost directly, but I'd expect that oxytocin treatment could potentially reduce healthcare costs in the long run by reducing relapse rates and improving treatment outcomes for methamphetamine dependence. Morley et al. discuss pharmacotherapeutic agents in the treatment of methamphetamine dependence, which could provide insight into the economic benefits of oxytocin treatment.
Patient Outcomes: With oxytocin's potential to enhance adult hippocampal neurogenesis, I'd expect to see improved patient outcomes in terms of reduced relapse rates and improved recovery from methamphetamine dependence. Akers et al. found that hippocampal neurogenesis regulates forgetting during adulthood, which suggests that oxytocin treatment could help patients forget methamphetamine-associated reward memories and reduce the risk of relapse.
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