Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes
ID: NCT06571500
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The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the University of Missouri. Our aim is to advance understanding of how growth hormone affects beta-cells and risk factors for developing type 2 diabetes.
Treatment Arms Description
- 18 to 59 years old
- body mass index ≥30.0 kg/m2 and \<45.0 kg/m2
- Family history of type 2 diabetes: first degree relative with type 2 diabetes
- Control group: no family history of type 2 diabetes
- Pregnant, planning to become pregnant during the study, or breastfeeding
- Current diagnosis or history of type 1 or type 2 diabetes
- Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
- History of bariatric surgery
- Known, uncontrolled hypothyroidism
- History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment
- Current cancer or cancer that has been in remission less than 5 years
- First degree relative with type 1 diabetes diagnosis
- Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)
- Alcohol use disorder, use of controlled substances, or smoking \>2 cigarettes per day
- Greater than 3% weight loss within three months of screening or engaged in regular (≥3 days per week), continuous moderate- or high-intensity exercise of ≥30 min duration
- Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent
Primary Outcome Measures
- Beta-cell function — Time Frame: before and 7 days after rhGH administration
Insulin secretion rate in relationship to plasma glucose
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View Official Medical/Scientific Title
Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes